Hypolipidemic Effects Of Diaceto-Dipropyl-Disulphide In Alloxan Diabetic Rats

Dr. Veena G. Raiker; Vickram

Hypolipidemic Effects Of Diaceto-Dipropyl-Disulphide In Alloxan Diabetic Rats

Dr. Veena G. Raiker * §

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Vickram

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ursvijay

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Kashinath R.T.

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§ Basaveshwara Medical College & Hospital

Hypolipidemic Effects Of Diaceto-Dipropyl-Disulphide In Alloxan Diabetic Rats

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Abstract

Dyslipidemia is one of the major derrangement observed in type 2 diabetes mellitus which further leads to various life threatening complications. Certain herbal disulphides/thiols are known to cater a solution towards regulation of this diabetes mellitus induced dyslipidemia. It is known that Diallyl Disulphide (DADS), a component of garlic extract possess hypolipidemic activities and may have therapeutic applications, but the metabolite of DADS, acrolein is toxic and poses certain disadvantages. Certain modified /altered disulphides, shown to possess significant hypolipidemic action with lesser toxic effects. In the present study, we tried to establish the hypolipidemic activities of Diaceto-Dipropyl-Disulphide (DADPDS), a synthetic modified disulphide in alloxan diabetic rats. The results show a significant decrease in plasma cholesterol (60%), plasma triacylglycerol (42%), liver tissue cholesterol (41%) and liver tissue triacylglycerol (23%),indicating the usefulness of this modified disulphide in controlling diabetes induced dyslipidemia.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Dr. Veena G. Raiker, Vickram, ursvijay, Kashinath R.T.. . "Hypolipidemic Effects Of Diaceto-Dipropyl-Disulphide In Alloxan Diabetic Rats". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 12 (GJMR Volume 12 Issue B5).

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GJMR Volume 12 Issue B5

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

alloxan diabetes Diaceto Dipropyl Disulphide hypolipidemic

Classification

GJMR-B Classification FOR Code: WD 200.5.H8

WF 141

WK 835

Submission ReceivedMarch 14, 2012
Peer Review Double Blind
Handling Editor
Accepted April 5, 2012
Published April 19, 2012

Version of record

v1.2

Language

English

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Article Matrices

Total Score: 149

Country: India

Subject: Global Journal of Medical Research

Authors: Dr. Veena G. Raiker, Vickram, Vijay V, Kashinath R.T (PhD/Dr. count: 1)

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Publish Date: 2012 04, Thu

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