In vitro and in-vivo studies of tolmetin release from natural gel base extracted from Okra seed (Abelmoschus esculentus) that cultivated in Egypt

Sayed H. Auda

In vitro and in-vivo studies of tolmetin release from natural gel base extracted from Okra seed (Abelmoschus esculentus) that cultivated in Egypt

Sayed H. Auda * §

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Al-Azhar University

In vitro and in-vivo studies of tolmetin release from natural gel base extracted from Okra seed (Abelmoschus esculentus) that cultivated in Egypt

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Abstract

Tolmetin is a non-steroidal anti-inflammatory drug commonly used for the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and periarticular disorders. In this work, we prepared and evaluated tolmetin release from mucilage extracted from Okra (Abelmoschus esculentus L) as a natural gel base. The in vitro release of tolmetin from natural gel base was studied using Franz diffusion cells with cellophane membrane placed between the donor and the receptor compartments. Possibility of solid state changes of Tolmetin with Okra seed mucilage (OSM) was studied using differential scanning calorimetery (DSC). The anti-inflammatory activity of tolmetin from natural gel base was evaluated using the carrageenan induced rat paw edema method. The results revealed that the in-vitro release of tolmetin from OSM without any additives was about 75 % after 180 minutes. The drug was transformed from solid state to amorphous one indicating that there is a physical interaction between tolmetin and OSM in gel form. At the same time there is no interaction was observed in case of physical mixture. Finally, tolmetin from OSM gel base gave a significant anti-inflammatory activity when compared with reference.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Sayed H. Auda. 1970. "In vitro and in-vivo studies of tolmetin release from natural gel base extracted from Okra seed (Abelmoschus esculentus) that cultivated in Egypt". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 12 (GJMR Volume 12 Issue B2).

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GJMR Volume 12 Issue B2

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

In-vitro and In-vivo studies mucilage Natural Gel base Okra seed Tolmetin

Classification

GJMR-B Classification NLMC Code: WQ 208

Submission ReceivedDecember 25, 2011
Peer Review Double Blind
Handling Editor
Accepted January 14, 2012
Published January 26, 2012

Version of record

v1.2

Language

English

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Article Matrices

Total Score: 148

Country: Egypt

Subject: Global Journal of Medical Research

Authors: Dr. S. Abd El Rasoul, Sayed H. Auda,Alaa M. Nafady (PhD/Dr. count: 1)

View Count (all-time): 153

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Publish Date: 2012 01, Thu

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Total Views: 5K

Total Downloads: 392

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