Ketorolac Tromethiamine Tablets Targeting to Colon through Microbial Degradation and pH Dependence: Development and Roentogenographic Studies

Kalyani Chithaluru

Ketorolac Tromethiamine Tablets Targeting to Colon through Microbial Degradation and pH Dependence: Development and Roentogenographic Studies

Kalyani Chithaluru * §

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§ Kakatiya Unnivefrsity, Warangal

Ketorolac Tromethiamine Tablets Targeting to Colon through Microbial Degradation and pH Dependence: Development and Roentogenographic Studies

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Abstract

The present experiment was designed to develop colon specific drug delivery system of ketorolac tromethiamine (KT) for treatment of various colonic disorders. Matrix tablets were prepared by direct compression technique utilizing combination of guar gum with various types of biodegradable/pH dependent/hydrophilic retarders. Tablets evaluated for quality control tests and in-vitro liberation studies (24h). In vivo roentogenographic studies and stability studies performed for optimized formulation. KT containing combination of guar gum with HPMCP (Hypromellose Phthalate) 55S released negligible amount in 1.2 pH and 7.4 phosphate buffers and 70% released in 6.8 pH (simulated colonic fluid) whereas 95% of KT released in 6.8 pH buffer (ratcaecal content). In-vivo roentogenographic studies of optimized formulation (F10) showed location of the tablet at 30 mins, 3 h and 8 h was in stomach, caecum and ascending colon respectively. FT-IR & DSC reveals that no interaction between drug and used excipients.

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19 Cites in Article

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Kalyani Chithaluru. 2013. "Ketorolac Tromethiamine Tablets Targeting to Colon through Microbial Degradation and pH Dependence: Development and Roentogenographic Studies". Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 13 (GJMR Volume 13 Issue B5).

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GJMR Volume 13 Issue B5

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

colon target hpmcp 55s ketorolac tromethiamine roentogenographic studies

Classification

GJMR-B Classification NLMC Code: QV 786.5.T3

Submission ReceivedDecember 12, 2012
Peer Review Double Blind
Handling Editor
Accepted January 5, 2013
Published January 15, 2013

Version of record

v1.2

Issue date

October 24, 2013

Language

English

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Article Matrices

Total Score: 142

Country: India

Subject: Global Journal of Medical Research

Authors: Kalyani Chithaluru , Rama Rao Tadikonda (PhD/Dr. count: 0)

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