Low-Level Laser for Prevention of Chemotherapy-Induced Oral Mucositis in Pediatric Patients with Acute Leukemia, HC/UFMG 2012-2013

Natalice Sousa de Oliveira; Jos Carlos Serufo

Low-Level Laser for Prevention of Chemotherapy-Induced Oral Mucositis in Pediatric Patients with Acute Leukemia, HC/UFMG 2012-2013

Natalice Sousa de Oliveira * §

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Jos Carlos Serufo

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§ Departamento de ClAnica Mdica

Low-Level Laser for Prevention of Chemotherapy-Induced Oral Mucositis in Pediatric Patients with Acute Leukemia, HC/UFMG 2012-2013

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Abstract

Oral mucositis (OM) is the non-hematological toxicity with the highest prevalence and morbidity in anticancer treatment. This study evaluated the use of low-level laser for the prevention of chemotherapy-induced OM by comparing 101 cycles with prophylactic irradiation using a gallium aluminum arsenide (GaAlAs) laser diode (λ=660 nm; P=40 mW, dose of 4 J/cm²) and 121 cycles with no irradiation. The conditions associated with oral health, chemotherapy cycles, neutropenia patterns, infectious complications and nutritional status were evaluated. OM occurred in 41.9% of the cycles. The probability of developing OM in the final cycles (7 to 10) was 7.34 times higher than in the initial cycles (1 to 6); 4.19 times higher in febrile neutropenia than in physiological neutropenia; 2.08 times higher when a therapeutic antimicrobial drug was used; and 2.12 times higher when gingivitis was present.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Natalice Sousa de Oliveira, Jos Carlos Serufo. 2014. "Low-Level Laser for Prevention of Chemotherapy-Induced Oral Mucositis in Pediatric Patients with Acute Leukemia, HC/UFMG 2012-2013". Global Journal of Medical Research - J: Dentistry & Otolaryngology GJMR-J Volume 14 (GJMR Volume 14 Issue J2).

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GJMR Volume 14 Issue J2

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-J Classification NLMC Code: WB 350

Submission ReceivedDecember 14, 2013
Peer Review Double Blind
Handling Editor
Accepted December 31, 2013
Published January 15, 2014

Version of record

v1.2

Issue date

June 3, 2014

Language

English

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Article Matrices

Total Score: 145

Country: Brazil

Subject: Global Journal of Medical Research

Authors: Natalice Sousa de Oliveira, Clia Regina Moreira Lanza, Rachel Aparecida Ferreira Fernandes, Denise Vieira Travassos, Jos Carlos Serufo (PhD/Dr. count: 0)

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