RP-HPLC Method For The Determination Of Pramipexole Dihydrochloride In Tablet Dosage Form

Dr. P.Lavudu; A.Prameela Rani; petikam lavudu

RP-HPLC Method For The Determination Of Pramipexole Dihydrochloride In Tablet Dosage Form

Dr. P.Lavudu * §

Contact

A.Prameela Rani

Contact

petikam lavudu

Contact

research.lavudu2009

Contact

§ Vishnu Institute of Pharmaceutical Education & Research

RP-HPLC Method For The Determination Of Pramipexole Dihydrochloride In Tablet Dosage Form

Article Fingerprint

ReserarchID

MR0FQF6

RP-HPLC Method For The Determination Of Pramipexole Dihydrochloride In Tablet Dosage Form Banner

AI TAKEAWAY

Connecting with the Eternal Ground

Abstract

A simple, sensitive, rapid, selective, precise and accurate high performance liquid chromatographic method was developed and validated for the determination of Pramipexole dihydrochloride in bulk and tablet dosage forms. HPLC separation was carried out by reversed phase chromatography on a Thermo Scientific C18 column (250 mm × 4.6 mm, 5 μm), held at ambient temperature. The mobile phase consisted of methanol: acetonitrile (40:60 v/v), run at a flow rate of 1.0 ml/min and with UV detection at 263 nm. The method was found to be linear over an analytical range of 1-100 μg/ml with LOD = 0.075 μg/ml and LOQ = 0.227 μg/ml, respectively. The proposed method was validated successfully and applied to the quantification of the drug in tablet dosage forms.

References

21 Cites in Article

Reference Format

Thomas Hoerger,Mohan Bala,Clayton Rowland,Marianne Greer,Elizabeth Chrischilles,Robert Holloway (1998). Cost Effectiveness of Pramipexole in Parkinson??s Disease in the US.
James Bennett,Montford Piercey (1999). Pramipexole — a new dopamine agonist for the treatment of Parkinson's disease.
Y Kohno,S Takeuchi (2004). Pharmacological profiles and clinical effects of antiparkinsonian agent, pramipexole.
J Mierau,F Schneider,H Ensinger,C Chio,M Lajiness,R Huff (1995). Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors.
Trond Kvernmo,Sebastian Härtter,Erich Burger (2006). A review of the receptor-binding and pharmacokinetic properties of dopamine agonists.
M Millan,L Maiofiss,D Cussac,V Audinot,J Boutin,A Newman-Tancredi (2002). Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes.
Srinu Babu,G Raju,Cai (2007). Spectrophotometric determination of pramiexole dihydrochloride monohydrate.
B Gurupadayya,V Vishwajith,N Srujana (2009). Spectrophotometric methods for the estimation of pramipexole dihydrochloride in pharmaceutical formulations.
B Thangabalan,G Praveen Kumar D, Lavanya,Inthiaz Sk,C Deepthi,Manohar Babu,S,Vijayaraj Kumar,P (2011). Extractive Spectrophotometric Determination of Pramipexole Dihydrochloride in Pure and Pharmaceutical Formulations.
M Shubhangi,R Sunil (2011). Application of stability indicating high performance thin layer chromatographic method for quantitation of pramipexole in pharmaceutical dosage form.
Y Yau,M Jeffrey,D Glenn,T Rasmy,Nita (1996). Determination of pramipexole (U-98,528) in human plasma by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry.
R Nirogi,V Kandikere,W Shrivastava,K Mudigonda,S Maurya,D Ajjala (2007). Quantification of pramipexole in human plasma by liquid chromatography tandem mass spectrometry using tamsulosin as internal standard.
D Bharathi,K Hotha,P Sagar,S Kumar,A Naidu,R Mullangi (2009). Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of pramipexole in human plasma: application to a clinical pharmacokinetic study.
M Alessandro,K Ernst,M Emanuele,R Fabrizio,A Maria (2008). Analysis of the anti-Parkinson drug pramipexole in human urine by capillary electrophoresis with laser-induced fluorescence detection.
G Jayesh,V Ravindra,K Shobhana (2011). Development and validation of GC/MS method for determination of pramipexole in rat plasma.
M Yadav,R Rao,H Kurani,J Rathod,R Patel,P Singhal,P Shrivastav (2010). Validated Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry Method for the Determination of Pramipexole in Human Plasma.
D Pathare,A Jadhav,M Shingare (2006). Validated chiral liquid chromatographic method for the enantiomeric separation of pramipexole dihydrochloride monohydrate.
B Jančić,M Medenica,D Ivanović,A Malenović (2007). Experimental design in chromatographic analysis of pramipexole and its impurities.
Y Yau,D Glenn,Nita (1996). Determination of pramipexole (U-98,528) in human plasma and urine by high-performance liquid chromatography with electrochemical and ultraviolet detection.
Seshagiri Rao,Jvln,Anantha Kumar,D Mastanamma,S Srilakshmi,K (2009). Estimation of pramipexole by an RP-HPLC method.
G Srinubabu,K Jaganbabu,B Sudharani,K Venugopal,G Girizasankar,Jvlns Rao (2006). Development and validation of a LC method for the determination of pramipexole using an experimental design.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Dr. P.Lavudu, A.Prameela Rani, petikam lavudu, research.lavudu2009. 1970. "RP-HPLC Method For The Determination Of Pramipexole Dihydrochloride In Tablet Dosage Form". Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 12 (GJMR Volume 12 Issue C4).

More Citation Formats

Select Citation Style:

Download Citation

GJMR Volume 12 Issue C4

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Development Pramipexole dihydrochloride RP-HPLC Validation

Classification

GJMR-C Classification NLMC Code: QV 785 QV 786

QV 787

Submission ReceivedFebruary 18, 2012
Peer Review Double Blind
Handling Editor
Accepted March 16, 2012
Published March 28, 2012

Version of record

v1.2

Language

English

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Score: 149

Country: India

Subject: Global Journal of Medical Research

Authors: Dr. P.Lavudu, A.Prameela Rani, C.Balashekaran, V.Venumadhav (PhD/Dr. count: 1)

View Count (all-time): 201

Total Views (Real + Logic): 8262

Total Downloads (simulated): 439

Publish Date: 2012 03, Wed

Monthly Totals (Real + Logic):

Month 1: 41 views
Month 2: 35 views
Month 3: 43 views
Month 4: 39 views
Month 5: 28 views
Month 6: 36 views
Month 7: 43 views
Month 8: 31 views
Month 9: 34 views
Month 10: 28 views
Month 11: 55 views
Month 12: 19 views
Month 13: 33 views
Month 14: 23 views
Month 15: 41 views
Month 16: 32 views
Month 17: 37 views
Month 18: 31 views
Month 19: 33 views
Month 20: 43 views
Month 21: 35 views
Month 22: 34 views
Month 23: 29 views
Month 24: 29 views
Month 25: 44 views
Month 26: 40 views
Month 27: 17 views
Month 28: 39 views
Month 29: 24 views
Month 30: 34 views
Month 31: 40 views
Month 32: 45 views
Month 33: 44 views
Month 34: 40 views
Month 35: 27 views
Month 36: 27 views
Month 37: 38 views
Month 38: 14 views
Month 39: 38 views
Month 40: 30 views
Month 41: 19 views
Month 42: 28 views
Month 43: 26 views
Month 44: 24 views
Month 45: 24 views
Month 46: 32 views
Month 47: 41 views
Month 48: 36 views
Month 49: 37 views
Month 50: 28 views
Month 51: 18 views
Month 52: 20 views
Month 53: 22 views
Month 54: 42 views
Month 55: 16 views
Month 56: 33 views
Month 57: 45 views
Month 58: 10 views
Month 59: 28 views
Month 60: 37 views
Month 61: 31 views
Month 62: 28 views
Month 63: 27 views
Month 64: 28 views
Month 65: 24 views
Month 66: 31 views
Month 67: 31 views
Month 68: 20 views
Month 69: 29 views
Month 70: 34 views
Month 71: 29 views
Month 72: 23 views
Month 73: 23 views
Month 74: 35 views
Month 75: 32 views
Month 76: 14 views
Month 77: 40 views
Month 78: 37 views
Month 79: 29 views
Month 80: 37 views
Month 81: 45 views
Month 82: 25 views
Month 83: 37 views
Month 84: 38 views
Month 85: 31 views
Month 86: 32 views
Month 87: 34 views
Month 88: 42 views
Month 89: 34 views
Month 90: 30 views
Month 91: 37 views
Month 92: 44 views
Month 93: 33 views
Month 94: 50 views
Month 95: 42 views
Month 96: 25 views
Month 97: 15 views
Month 98: 32 views
Month 99: 39 views
Month 100: 30 views
Month 101: 41 views
Month 102: 42 views
Month 103: 40 views
Month 104: 47 views
Month 105: 29 views
Month 106: 42 views
Month 107: 41 views
Month 108: 30 views
Month 109: 33 views
Month 110: 33 views
Month 111: 46 views
Month 112: 20 views
Month 113: 21 views
Month 114: 39 views
Month 115: 21 views
Month 116: 35 views
Month 117: 40 views
Month 118: 37 views
Month 119: 26 views
Month 120: 35 views
Month 121: 16 views
Month 122: 38 views
Month 123: 29 views
Month 124: 34 views
Month 125: 23 views
Month 126: 43 views
Month 127: 43 views
Month 128: 43 views
Month 129: 39 views
Month 130: 17 views
Month 131: 19 views
Month 132: 42 views
Month 133: 49 views
Month 134: 25 views
Month 135: 25 views
Month 136: 29 views
Month 137: 30 views
Month 138: 16 views
Month 139: 35 views
Month 140: 42 views
Month 141: 48 views
Month 142: 41 views
Month 143: 22 views
Month 144: 26 views
Month 145: 29 views
Month 146: 16 views
Month 147: 21 views
Month 148: 28 views
Month 149: 27 views
Month 150: 40 views
Month 151: 27 views
Month 152: 47 views
Month 153: 32 views
Month 154: 17 views
Month 155: 44 views
Month 156: 36 views
Month 157: 42 views
Month 158: 40 views
Month 159: 22 views
Month 160: 38 views
Month 161: 55 views
Month 162: 21 views
Month 163: 24 views
Month 164: 30 views
Month 165: 34 views
Month 166: 49 views
Month 167: 36 views
Month 168: 26 views
Month 169: 43 views
Month 170: 49 views
Month 171: 24 views
Month 172: 54 views
Month 173: 58 views
Month 174: 42 views
Month 175: 44 views

Total Views: 8.3K

Total Downloads: 439

All Trends