Usefulness of an Initial Single Intravenous Immunoglobulin Therapy for Kawasaki Disease

Toshimasa Nakada

Usefulness of an Initial Single Intravenous Immunoglobulin Therapy for Kawasaki Disease

Toshimasa Nakada * §

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§ Aomori Prefectural Central Hospital

Usefulness of an Initial Single Intravenous Immunoglobulin Therapy for Kawasaki Disease

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Abstract

Kawasaki disease is an acute systemic vasculitis of unknown cause that affects mainly infants and children. Coronary artery lesions (CAL) are one of the most important complications of this disease. An appropriate therapy during acute phase of Kawasaki disease to prevent large CAL has not been established. Recent studies disclosed that aspirin and flurbiprofen appeared to have a negative impact on the suppressive effects of initial intravenous immunoglobulin (IVIG) therapy on CAL development in the acute phase of Kawasaki disease and that an initial single IVIG therapy with delayed administration of anti-inflammatory drugs might be useful for prevention of large CAL. Furthermore, recent study disclosed that variable factors including IVIG resistance, responsiveness, and relapse of disease were associated with CAL complications and that an initial single IVIG therapy may be useful for the prevention of large CAL caused by different factors of Kawasaki disease.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Toshimasa Nakada. 2015. "Usefulness of an Initial Single Intravenous Immunoglobulin Therapy for Kawasaki Disease". Global Journal of Medical Research - F: Diseases GJMR-F Volume 15 (GJMR Volume 15 Issue F4).

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GJMR Volume 15 Issue F4

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Classification

GJMR-F Classification NLMC Code: WO 285

Submission ReceivedApril 15, 2015
Peer Review Double Blind
Handling Editor
Accepted May 1, 2015
Published May 15, 2015

Version of record

v1.2

Issue date

November 2, 2015

Language

English

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Total Score: 186

Country: Japan

Subject: Global Journal of Medical Research

Authors: Toshimasa Nakada (PhD/Dr. count: 0)

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Publish Date: 2015 05, Fri

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