Viral Latency, Molecular Pathogenesis and Malignancy

Giulio Tarro

Viral Latency, Molecular Pathogenesis and Malignancy

Giulio Tarro * §

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§ Sbarro institute for Cancer Research and Molecular M...

Viral Latency, Molecular Pathogenesis and Malignancy

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Connecting with the Eternal Ground

Abstract

Viruses are a major component of the biosphere, entering cells and genomes to insert their own genetic material. Herpesvirus lies hidden for years in the cells of the nervous system before emerging to cause herpes vesicles at the body surface. In the ‘virosphere’ there are the retroviruses, whose RNA genome can be converted to DNA by the reverse transcriptase enzyme carried in their viral particles, integrating their genes into the host cell genome and becoming one with it. When, for any of a number of reasons, the host immune system undergoes degrees of immunosoppression, the virus can reactivate, replicate, and cause disease. Even when this does not occur, oncogenic virus latency can induce malignancy in host cells.

References

50 Cites in Article

Reference Format

A Baldwin,K Munger (2010). Molecular events associated with human papillomavirus-induced human cancers in Viral Oncology.
N Baranova,M Carbone (2010). Laura Hengehold et Nancy Bauer (dir.). A Companion to Simone de Beauvoir . Hoboken (New Jersey), Wiley Blackwell, coll. « Blackwell Companions to Philosophy », 2017, 530 p..
T Block,A Mehta (2010). Molecular immunobiology of hepatitis B-associated viral cancer in Viral Oncology.
R Boland,L Ricciardiello,A Goel (2010). Involvement of the polyomavirus, JC virus, in colorectal cancer in Viral Oncology.
Robert Bowles,John Blaho (2011). A truncation mutation of the neurovirulence ICP22 protein produced by a recombinant HSV-1 generated by bacterial artificial chromosome technology targets infected cell nuclei.
J Butel (2010). Simian virus 40, human infections, and cancer: emerging concepts and causality considerations in Viral Oncology.
M-H Chang,D-S Chen (2010). Hepatitis B vaccine and hepatocellular carcinoma in Viral Oncology.
J Chen,A Gershon,Z Li,R Gershon,M (2011). Varicella zoster virus (VZV) infects and established latency in enteric neurons.
Gerardo Chowell,Stefano Bertozzi,M Colchero,Hugo Lopez-Gatell,Celia Alpuche-Aranda,Mauricio Hernandez,Mark Miller (2009). Severe Respiratory Disease Concurrent with the Circulation of H1N1 Influenza.
Charles Cobbs (2012). Evolving evidence implicates cytomegalovirus as a promoter of malignant glioma pathogenesis.
Randall Cohrs,Don Gilden (2012). Alphaherpesvirus latency.
W Dar,B Sugden (2010). Epstein-Barr virus as a pathogen.
F Dawood,S Jain,L Finelli (2009). Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans.
G De Falco,C Bellan,S Lazzi,L Leoncini (2010). HIV-related lymphoma in Viral Oncology.
L Ellis,X Dang,Norton Koralnik (2012). Role of agnogene deletion and archetype-like regulatory region in a JCV strain isolated from the brain of a patient with JCV encephalopathy (JCVE).
Martin Enserink,Jon Cohen (2009). The Novel H1N1 Influenza.
C Esposito,Di Spirito,A Cuomo,N (2012). Tracking the 2009 H1N1 influenza virus in the Italian region Campania.
Mark Feitelson,H Reis,J Pan,B Sun (2010). Hepatitis B Virus and Cancer.
Olivera Finn (2008). Cancer Immunology.
G Hayward,J Donald,R Arav-Boger (2010). The role of KSHV in pathogenesis of Kaposi's sarcoma in Viral Oncology.
K Held,T Derfuss (2012). Control of HSV-1 latency in human trigeminal ganglia -current overview.
M Imperiale,D Das (2010). Possible association of BK virus with prostate cancer in Viral Oncology.
Paola Indovina,Eleonora Marcelli,Francesca Pentimalli,Piero Tanganelli,Giulio Tarro,Antonio Giordano (2012). Mass spectrometry‐based proteomics: The road to lung cancer biomarker discovery.
Paola Indovina,Eleonora Marcelli,Pasquale Maranta,Giulio Tarro (2011). Lung Cancer Proteomics: Recent Advances in Biomarker Discovery.
R Katrenellenbogen,D Galloway (2010). Human papillomavirus-associated cancers in Viral Oncology.
Paul Kinchington,William Goins (2011). Varicella zoster virus-induced pain and post-herpetic neuralgia in the human host and in rodent animal models.
Paula Lister,Fiona Reynolds,Roger Parslow,Alex Chan,Mehrengise Cooper,Adrian Plunkett,Shelly Riphagen,Mark Peters (2009). Swine-origin influenza virus H1N1, seasonal influenza virus, and critical illness in children.
S Marriott (2010). Oncogenic potential of the HTLV-1 tax protein in Viral Oncology.
M Matsuoka (2010). Clinical aspects of HTLV-1associated cancer in Viral Oncology.
V Minhas,C Wood (2010). Biology and epidemiology of HHV-8 in Viral Oncology.
David Morens,Jeffery Taubenberger,Anthony Fauci (2009). The Persistent Legacy of the 1918 Influenza Virus.
J Pagano (2010). Molecular pathobiology of EBV infection in Viral Oncology.
Sonia Perez,Eric Von Hofe,Nikoletta Kallinteris,Angelos Gritzapis,George Peoples,Michael Papamichail,Constantin Baxevanis (2010). A new era in anticancer peptide vaccines.
A Rathi,J Pipas (2010). Oncogenic transformation by polyomavirus large T antigen in Viral Oncology.
K Reiss,K Khalili,Del Valle,L (2010). JC virus association with brain tumors: the role of T antigen and insulin-like growth factor 1 in DNA repair fidelity in Viral.
Bernard Roizman,Guoying Zhou,Te Du (2012). Checkpoints in productive and latent infections with herpes simplex virus 1: conceptualization of the issues.
N Sawtell,S Triezenberg,R Thompson (2011). VP16 serine 375 is a critical determinant of herpes simplex virus exit from latency in vivo.
L Schiller (2008). Noninvasive Monitoring of Tumors.
D Sir,J-H J Ou (2010). Molecular Mechanisms of hepatitis C virus-induced cellular transformation in Viral.
G Stix (2007). A malignant flame.
St,A Leger,R Hendricks (2012). CD8+ T cells patrol HSV-1-infected trigeminal ganglia and prevent viral reactivation.
Giulio Tarro (2009). Tumor liberated protein from lung cancer and perspectives for immunotherapy.
G Tarro,C Esposito (2011). Emerging viral agents at risk in global health approaches to early diagnosis and prompt therapy.
Giulio Tarro,Antonio Perna,Ciro Esposito (2005). Early diagnosis of lung cancer by detection of tumor liberated protein.
M Thomas,D Pim,L Banks (2010). The role of the human papillomavirus E6 oncoprotein in malignant progression in Viral Oncology.
Richard Thompson,Nancy Sawtell (2011). The herpes simplex virus type 1 latency associated transcript locus is required for the maintenance of reactivation competent latent infections.
Matteo Vergati,Chiara Intrivici,Ngar-Yee Huen,Jeffrey Schlom,Kwong Tsang (2010). Strategies for Cancer Vaccine Development.
L Zerboni,Arvin (2011). Investigation of varicellazoster virus neurotropism and neurovirulence using SCID mouse-human DRG xenografts.
Shanta Zimmer,Donald Burke (2009). Historical Perspective — Emergence of Influenza A (H1N1) Viruses.
Zur Hausen,H (2007). Infections causing human cancer.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Giulio Tarro. 2014. "Viral Latency, Molecular Pathogenesis and Malignancy". Global Journal of Science Frontier Research - C: Biological Science GJSFR-C Volume 14 (GJSFR Volume 14 Issue C3).

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GJSFR Volume 14 Issue C3

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords

herpesvirus latency oncogenic viruses papillomavirus T antigens

Classification

GJSFR-C Classification FOR Code: 270000

Submission ReceivedAugust 7, 2014
Peer Review Double Blind
Handling Editor
Accepted September 1, 2014
Published September 16, 2014

Version of record

v1.2

Issue date

September 24, 2014

Language

English

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Total Score: 145

Country: Italy

Subject: Global Journal of Science Frontier Research

Authors: Giulio Tarro (PhD/Dr. count: 0)

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