Evaluation of Invitro Anti-Inflammatory Potential of Aqueous Solanum Aethiopicum (Garden Egg) Leaf Extract

Evaluation of Invitro Anti-Inflammatory Potential of Aqueous Solanum Aethiopicum (Garden Egg) Leaf Extract

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Afuye Olukorede Oyewale

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Olasunkanmi A.A.

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Evaluation of Invitro Anti-Inflammatory Potential of Aqueous Solanum Aethiopicum (Garden Egg) Leaf Extract

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Abstract

Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells or irritants. This study is aimed at evaluating the invitro antiinflammatory potential of aqueous leaves extract of Solanum aethiopicum (Family: Solanaceae). In vitro anti-inflammatory potentials were evaluated using standard experimental protocols such as Inhibition of albumin denaturation, Anti-lipoxygenase activity, Membrane stabilization and Proteinase inhibitory action at different concentrations with aspirin and diclofenac used as the standard drug. Aqueous extract of S.aethiopicum leaves were tested for the presence of alkaloid, flavonoid, tannin, glycoside, steroids, phenol and terpenoids. The total phenol and flavonoid content were evaluated as well. The total phenol and flavonoid content were found to be (132±0.13 mg of Gallic acid/g of equivalent) and (146±1.12mg of Quercetin/g of equivalent).The IC 50 values of the extract, diclofenac and aspirin (standard drug) in inhibition of albumin denaturation were 50.20 µg/ml and 31.54µg/ml; in Anti-lipoxygenase activity were 199µg/ml and 28.2µg/ml; in Membrane stabilization were 9.36µg/ml and 19.85µg/ml and Protein Denaturation 714µg/ml and 23.5 µg/ml.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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How to Cite This Article

afuye_olukorede_oyewale. 2021. \u201cEvaluation of Invitro Anti-Inflammatory Potential of Aqueous Solanum Aethiopicum (Garden Egg) Leaf Extract\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 21 (GJSFR Volume 21 Issue B2).

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GJSFR Volume 21 Issue B2

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Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

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GJSFR-B Classification FOR Code: 259999p

Submission ReceivedFebruary 28, 2021
Peer Review Double Blind
Handling Editor
Accepted March 24, 2021
Published April 8, 2021

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September 3, 2021

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