A New, Phenotypically Distinct Subpopulation of Regulatory Killer T ex-Th17 Cells Expressing CD4lowCD25hiCD49hiFoxp3hiRORlowIL-17low

A New, Phenotypically Distinct Subpopulation of Regulatory Killer T ex-Th17 Cells Expressing CD4lowCD25hiCD49hiFoxp3hiRORlowIL-17low

Article ID

4LG0Q

A New, Phenotypically Distinct Subpopulation of Regulatory Killer T ex-Th17 Cells Expressing CD4lowCD25hiCD49hiFoxp3hiRORlowIL-17low

Maria S. Sayapina Osaka University

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Abstract

Th17 and regulatory T (Treg) cells are integral in maintaining immune homeostasis and Th17– Treg imbalance has been associated with inflammatory immunosuppression in cancer. Here it is shown that in addition to ROR+Foxp3+ cells eTreg (Effector Regulatory T Cells) cells are a source of ex-Th17 CD4 low CD25 hi CD49 hi Foxp3 hi (Regulatory Killer T – RKT) cells while the latest is much more suppressive. Moreover, we have identified a set of key cytokines that favor the generation and expansion of ex-Th17 Foxp3 low cells. These findings should accelerate efforts to define the function of this new subset of Treg cells in the immune response to cancer.

A New, Phenotypically Distinct Subpopulation of Regulatory Killer T ex-Th17 Cells Expressing CD4lowCD25hiCD49hiFoxp3hiRORlowIL-17low

Authors

Maria S. Sayapina Osaka University

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How to Cite

Maria S. Sayapina. 2018. “. Global Journal of Science Frontier Research – C: Biological Science GJSFR-C Volume 18 (GJSFR Volume 18 Issue C3): .

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

GJSFR Volume 18 Issue C3
Pg. 31- 37

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Classification

GJSFR-C Classification: FOR Code: 069999

Submission Received July 26, 2018
Accepted August 21, 2018
Published September 2, 2018

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Article Matrices

Total Score: 146

Country: Japan

Subject: Global Journal of Science Frontier Research - C: Biological Science

Authors: Maria S. Sayapina (PhD/Dr. count: 0)

View Count (all-time): 135

Total Views (Real + Logic): 3108

Total Downloads (simulated): 1453

Publish Date: 2018 08, Sat

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Total Views: 3108

Total Downloads: 1453

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