Association with the Development and Menorracy of Polymorphism Rs2046934 of the P2ry12 Gene in Patients with  Dysaggregation Thrombocytopathies.

Association with the Development and Menorracy of Polymorphism Rs2046934 of the P2ry12 Gene in Patients with Dysaggregation Thrombocytopathies.

Surayyo Z. Yuldasheva

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Shakhnoza G. Sabirova

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Association with the Development and Menorracy of Polymorphism Rs2046934 of the P2ry12 Gene in Patients with Dysaggregation Thrombocytopathies.

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Abstract

The results of studying the peculiarities of the P2RY12 gene polymorphism (rs2046934) revealed in the main group of road traffic accidents an increase in the proportion of the unfavorable allele A by 2.24 times (χ2=3.61; P=0.06; OR=2.24) in relation to the control, which indicates the presence of a tendency towards the risk of developing disaggregated thrombocytopathies. In addition, there was an increase among patients with NDTP of the mutant genotype A / A (χ2=3.04; P=0.08). Indicates a tendency towards an increased risk of development and associative relationship with the clinic (namely with menorrhagia) (χ2=5.6; P=0.02; OR=4.3) of this disease.

References

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Reference Format

Chaker Aloui,Tahar Chakroun,Viviana Granados,Saloua Jemni-Yacoub,Jocelyne Fagan,Abderrahim Khelif,Najoua Kahloul,Sabeur Hammami,Latifa Chkioua,Céline Barlier,Fabrice Cognasse,Sandrine Laradi,Olivier Garraud (2018). Molecular genetic diagnosis of Tunisian Glanzmann thrombasthenia patients reveals a common nonsense mutation in the ITGA2B gene that seems to be specific for the studied population.
Meera Chitlur,Madhvi Rajpurkar,Michael Recht,Michael Tarantino,Donald Yee,David Cooper,Sriya Gunawardena (2017). Recognition and management of platelet-refractory bleeding in patients with Glanzmann’s thrombasthenia and other severe platelet function disorders.
R Diz-Kucukkaya (2013). Inherited platelet disorders including Glanzmann thrombasthenia and Bernard-Soulier syndrome.
T Drogies,L Braunert,J Thiery,M Brügel (2011). Thrombocytopathy: an update.
Katalin Koltai,Gabor Kesmarky,Gergely Feher,Antal Tibold,Kalman Toth (2017). Platelet Aggregometry Testing: Molecular Mechanisms, Techniques and Clinical Implications.
A Lecchi,C Razzari,S Paoletta,A Dupuis,L Nakamura,P Ohlmann,C Gachet,K Jacobson,B Zieger,M Cattaneo (2015). Identification of a new dysfunctional platelet P2Y12 receptor variant associated with bleeding diathesis.
S Mundell,D Rabbolini,S Gabrielli (2017). Receptor homodimerization plays a critical role in a novel dominant negative P2RY12 variant identified in a family with severe bleeding.
L Miao,F Gan,Y Gong (2018). Molecular analysis of gene mutations in eight patients with Glanzmann's thrombasthenia.
Paolo Gresele,Emanuela Falcinelli (2016). Loredana Bury Inherited platelet function disorders: Diagnostic approach and management JHamostaseologie.
Y Patel,M Lordkipanidzé,G Lowe,S Nisar,K Garner,J Stockley,M Daly,M Mitchell,S Watson,S Austin,S Mundell (2014). A novel mutation in the P2Y12 receptor and a function‐reducing polymorphism in protease‐activated receptor 1 in a patient with chronic bleeding.
Madhvi Rajpurkar,Sarah O'brien,Fareeda Haamid,David Cooper,Sriya Gunawardena,Meera Chitlur (2016). Heavy Menstrual Bleeding as a Common Presenting Symptom of Rare Platelet Disorders: Illustrative Case Examples.
Anne Rocheleau,Ayesha Khader,Anh Ngo,Colin Boehnlein,Cara Mcdavitt,Susan Lattimore,Michael Recht,Owen Mccarty,Kristina Haley (2018). Pilot study of novel lab methodology and testing of platelet function in adolescent women with heavy menstrual bleeding.
Shawn Jobe,Jorge Di Paola (2019). Congenital and Acquired Disorders of Platelet Function and Number.
L Zhou,M Jiang,H Shen,T You,Z Ding (2018). Clinical and molecular insights into Glanzmann's thrombasthenia in China.
Thomas Blair,Alan Michelson,Andrew Frelinger (2018). Mass Cytometry Reveals Distinct Platelet Subtypes in Healthy Subjects and Novel Alterations in Surface Glycoproteins in Glanzmann Thrombasthenia.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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How to Cite This Article

Surayyo Z. Yuldasheva. 2026. \u201cAssociation with the Development and Menorracy of Polymorphism Rs2046934 of the P2ry12 Gene in Patients with Dysaggregation Thrombocytopathies.\u201d. Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 22 (GJMR Volume 22 Issue C1).

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-C Classification DDC Code: 362.1 LCC Code: R727.45

Submission ReceivedJanuary 8, 2022
Peer Review Double Blind
Handling Editor
Accepted January 28, 2022
Published February 7, 2022

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March 17, 2022

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