Cytokine Storm: A Suicidal Immune Response to Novel Corona Virus

Cytokine Storm: A Suicidal Immune Response to Novel Corona Virus

jignakumari_j._gohil

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Jignakumari J. Gohil

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Chiragkumar J. Gohil

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Cytokine Storm: A Suicidal Immune Response to Novel Corona Virus

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Abstract

SARS-CoV-2 virus is responsible for the COVID-19 disease in patients. Only 15-20 % of COVID-19 patients have developed severe pulmonary symptoms and illness, which are fatal to patients. Hyperimmune response to the SARS-CoV-2 virus by the host’s immune system causes the release and over production of certain kinds of inflammatory mediators and cytokines. And it results in the cytokine storm. Cytokine storm produces the hyper inflammatory reaction, which deteriorates the cells and tissue. This type of immune response is host killing and suicidal response to the SARS-CoV-2 virus by the host. This suicidal response ultimately leads to lung damage, respiratory tract pneumonia, ARDS, multi-organ failure at a later stage and ultimately death. Hence, it needs to suppress the hyper-functioning of the immune system to inhibit the cytokine release and cytokine storm. Anti-inflammatory and immuno-modulatory drugs can be repurposed to manage the cytokine storm and hyper-immune response. Inhibition and management of the host’s suicidal immune response and cytokine storm, could be life-saving and reduce the mortality rate in COVID-19 patients.

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No external funding was declared for this work.

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The authors declare no conflict of interest.

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How to Cite This Article

jignakumari_j._gohil. 2021. \u201cCytokine Storm: A Suicidal Immune Response to Novel Corona Virus\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 21 (GJMR Volume 21 Issue B1).

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GJMR Volume 21 Issue B1

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification NLMC Code: QW 640

Submission ReceivedJune 8, 2021
Peer Review Double Blind
Handling Editor
Accepted July 3, 2021
Published July 15, 2021

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v1.2

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March 22, 2021

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