Association of Rs763780 Polymorphism of Gene IL17F with the Risk of Developing Rheumatoid Arthritis in Uzbekistan

Association of Rs763780 Polymorphism of Gene IL17F with the Risk of Developing Rheumatoid Arthritis in Uzbekistan

Surayyo Z. Yuldasheva

Contact

M. Sh. Karimov

Contact

A. A. Eshmurzaeva

Contact

Kh. M. Marufkhanov

Contact

M. V. Sibirkina

Contact

Association of Rs763780 Polymorphism of Gene IL17F with the Risk of Developing Rheumatoid Arthritis in Uzbekistan

Article Fingerprint

ReserarchID

FQKH8

Association of Rs763780 Polymorphism of Gene IL17F with the Risk of Developing Rheumatoid Arthritis in Uzbekistan Banner

AI TAKEAWAY

Connecting with the Eternal Ground

Abstract

As a result of the study conducted, it was witnessed that the G allele and the heterozygous A / G genotype of the IL17F gene (rs763780) among patients with RA are significantly higher than in the control group. In particular, the most significant discrepancies were registered in patients with articular-visceral form of the disease whom the G allele exceeded the proportion of carriage in the control statistically significantly 2.58 times (χ2 = 4.512; P = 0.037; OR = 2.58; 95% CI: 1.076 -6.188). On the part of the heterozygous genotype A / G there was a clear tendency to increase its frequency by more than twice (χ2 = 2.011; P = 0.165; OR = 2.068; 95% CI: 0758-5.645) which in turn indicates the possible participation of the studied polymorphism in the pathogenesis of RA.

References

18 Cites in Article

Reference Format

D Aletaha,T Neogi,A Silman (2010). Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League against Rheumatism collaborative initiative.
Robert Ball,Alison Avenell,Lorna Aucott,Peter Hanlon,Mark Vickers (2015). Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and rheumatoid arthritis.
Marie-Christophe Boissier,Luca Semerano,Salima Challal,Nathalie Saidenberg-Kermanac'h,Géraldine Falgarone (2012). Rheumatoid arthritis: From autoimmunity to synovitis and joint destruction.
C Carvalho,R Carmo,E Duarte,A Carvalho,J Leão,C Gueiros (2015). Unknown Title.
Adam Cribbs,Alan Kennedy,Henry Penn,Parisa Amjadi,Patricia Green,Jordan Read,Fionula Brennan,Bernard Gregory,Richard Williams (2015). Methotrexate Restores Regulatory T Cell Function Through Demethylation of the FoxP3 Upstream Enhancer in Patients With Rheumatoid Arthritis.
M Cross,E Smith,D Hoy,L Carmona (2014). Unknown Title.
Gary Firestein,Anna-Karin H. Ekwall (2018). Rheumatoid Arthritis: Etiology and Pathogenesis.
Anna Hedström,Leszek Stawiarz,Lars Klareskog,Lars Alfredsson (2018). Smoking and susceptibility to rheumatoid arthritis in a Swedish population-based case–control study.
Nastya Kharlamova,Xia Jiang,Natalia Sherina,Barbara Potempa,Lena Israelsson,Anne‐marie Quirke,Kaja Eriksson,Tülay Yucel‐lindberg,Patrick Venables,Jan Potempa,Lars Alfredsson,Karin Lundberg (2013). Antibodies to <i>Porphyromonas gingivalis</i> Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology.
Young Lee,Sang-Cheol Bae (2017). Associations between circulating IL-17 levels and rheumatoid arthritis and between IL-17 gene polymorphisms and disease susceptibility: a meta-analysis.
S Louahchi,I Allam,N Raaf,L Berkani,A Boucharef,A Abdessemed,N Khaldoun,N Bahaz,A Ladjouze‐rezig,A Nebbab,M Ghaffor,R Djidjik (2016). Association of rs6822844 within the <scp>KIAA1109</scp>/<scp>TENR</scp>/<scp>IL2</scp>/<scp>IL21</scp> locus with rheumatoid arthritis in the Algerian population.
Ouled Marwa,Tizaoui Kalthoum,Kaabachi Wajih,Hamzaoui Kamel (2017). Association of IL17A and IL17F genes with rheumatoid arthritis disease and the impact of genetic polymorphisms on response to treatment.
S Miller,D Dykes,H Polesky (1988). A simple salting out procedure for extracting DNA from human nucleated cells.
Marina Nemtsova,Dmitry Zaletaev,Irina Bure,Dmitry Mikhaylenko,Ekaterina Kuznetsova,Ekaterina Alekseeva,Marina Beloukhova,Andrei Deviatkin,Alexander Lukashev,Andrey Zamyatnin (2019). Epigenetic Changes in the Pathogenesis of Rheumatoid Arthritis.
Andrzej Pawlik,Daniel Kotrych,Damian Malinowski,Violetta Dziedziejko,Michal Czerewaty,Krzysztof Safranow (2016). IL17A and IL17F gene polymorphisms in patients with rheumatoid arthritis.
J Potempa,J Mydel,P Koziel,J (2017). The case for periodontitis in the pathogenesis of rheumatoid arthritis.
Hans Scherer,Thomas Häupl,Gerd Burmester (2019). The etiology of rheumatoid arthritis.
Ming Shao,Shanshan Xu,Hui Yang,Wei Xu,Jixiang Deng,Yuting Chen,Xing Gao,Shiyang Guan,Shengqian Xu,Zongwen Shuai,Faming Pan (2020). Association between IL-17A and IL-17F gene polymorphism and susceptibility in inflammatory arthritis: A meta-analysis.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Surayyo Z. Yuldasheva. 2021. \u201cAssociation of Rs763780 Polymorphism of Gene IL17F with the Risk of Developing Rheumatoid Arthritis in Uzbekistan\u201d. Global Journal of Medical Research - H: Orthopedic & Musculoskeletal System GJMR-H Volume 21 (GJMR Volume 21 Issue H2).

More Citation Formats

Select Citation Style:

Download Citation

GJMR Volume 21 Issue H2

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Not Found

Classification

GJMR-H Classification NLMC Code: WE 346

Submission ReceivedDecember 12, 2020
Peer Review Double Blind
Handling Editor
Accepted January 3, 2021
Published January 15, 2021

Version of record

v1.2

Issue date

September 15, 2021

Language

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Views: 2081

Total Downloads: 994

2026 Trends

Our website is actively being updated, and changes may occur frequently. Please clear your browser cache if needed. For feedback or error reporting, please email [email protected]