Histological Features of Scar Tissue Formation in Different Methods of Postoperative Wound Closure

Histological Features of Scar Tissue Formation in Different Methods of Postoperative Wound Closure

Nataliia Lytovchenko

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Zhurakovska Galina

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Savosko Serhii

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Bogomolets National Medical University

Histological Features of Scar Tissue Formation in Different Methods of Postoperative Wound Closure

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Abstract

The aim is to study the features of histological and morphometric changes of skin scars in different variants of soft tissue wound closure. Materials and methods: 60 Wistar rats, divided into 5 groups, were operated on: control group and 4 experimental ones: interrupted (loop) sutures, subcuticular suture, adhesion with dermal glue “Dermabond”, interconnection with high freaquency electrocoagulator – HFEW. Skin regeneration and scar formation were studied with histological and morphometric methods on 7th and 14th day. Results: On the day 7 after the closure of the wound defect, the thickness of the perifocal epidermis was significantly increased by 1.5-2.4 times due to reepithelialization and the formation of granulation tissue. No morphological differences in skin regeneration after interrupted and subcuticular sutures were found. Application of “Dermabond” and HFEW caused progressive increase thickness of the epithelium.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Nataliia Lytovchenko. 2026. \u201cHistological Features of Scar Tissue Formation in Different Methods of Postoperative Wound Closure\u201d. Global Journal of Medical Research - K: Interdisciplinary GJMR-K Volume 23 (GJMR Volume 23 Issue K3).

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GJMR Volume 23 Issue K3

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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Classification

GJMR-K Classification NLM: WO 600

Submission ReceivedMarch 27, 2023
Peer Review Double Blind
Handling Editor
Accepted April 3, 2023
Published May 24, 2023

Version of record

v1.2

Issue date

May 24, 2023

Language

English

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