Cows Milk Protein Allergy in Children with Inherited Epidermolysis Bullosa
Background: Epidermal barrier dysfunction, which is observed in children with inherited epidermolysis bullosa (EB) from the first days of life, can cause sensitization, including sensitization to food. Objective: Evaluate the features of the IgE response to cow’s milk protein (CMPA) in children with EB. Methods: We examined 94 patients with EB – 72 children with dystrophic EB and 22 – with EB simplex. Assessment of the total wound burden and disease severity was based on “The Epidermolysis Bullosa Disease Activity and Scarring Index” (EBDASI). Diagnosis of CMPA was based on a generally accepted set of clinical and laboratory methods (natural history of disease, clinical manifestations, elimination diet, provocation tests). The level of specific IgE for cow’s milk proteins and its fractions (casein, β-lactoglobulin, bovine serum albumin) was determined by indirect immune of luorescence method (Immuno CAP 250).
