Proniosomal Gel: Formulation and Charecterization of an Antifungal Drug (Butenafine HCL) Loaded Proniosomes for Topical Delivery

Proniosomal Gel: Formulation and Charecterization of an Antifungal Drug (Butenafine HCL) Loaded Proniosomes for Topical Delivery

Thimmaraju D R

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Dr. Abdul Nasir Kurnool

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Adichunchanagiri College of Pharmacy

Proniosomal Gel: Formulation and Charecterization of an Antifungal Drug (Butenafine HCL) Loaded Proniosomes for Topical Delivery

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Abstract

The present proniosomal gel investigation was aimed to minimize the adverse effects associated with present topical butenafine hydrochloride formulations and made to enhance its bioavailability and sustained release by novel proniosomal drug delivery system. Butenafine hydrochloride is an allylamine class of advanced antifungal drug. Which mainly recommended to treat long term topical fungal infection. Proniosomes were prepared by slurry method using different concentrations of non-ionic surfactant (span and tween) and evaluated various parameter like surface morphology, entrapment efficiency, drug content, viscosity, drug content, in-vitro % drug release, in-vitro fungal activity and stability studies. The results showed that formulation (F3) containing span 60: cholesterol (1:2) showed highest drug content (99.13%) and entrapment efficiency (79.87%) compared to other formulations. The pH and viscosity of prepared all proniosomal gel formulation were found in range (5.40-6.11) and (8920-14400CPs) correspondingly.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Thimmaraju D R. 2020. \u201cProniosomal Gel: Formulation and Charecterization of an Antifungal Drug (Butenafine HCL) Loaded Proniosomes for Topical Delivery\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 20 (GJMR Volume 20 Issue B5).

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GJMR Volume 20 Issue B5

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-B Classification NLMC Code: QV 252

Submission ReceivedDecember 9, 2019
Peer Review Double Blind
Handling Editor
Accepted January 1, 2020
Published January 15, 2020

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v1.2

Issue date

July 27, 2020

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