Liver Damage in Pediatric Critically Ill COVID-19 Patients: Brazilian Case-Series

1
werther_brunow_de_carvalho
werther_brunow_de_carvalho
2
Werther Brunow De Carvalho
Werther Brunow De Carvalho
3
Michele Luglio
Michele Luglio
4
Uenis Tannuri
Uenis Tannuri
5
Maria Fernanda Badue Pereira
Maria Fernanda Badue Pereira
6
Isadora Souza Rodrigues
Isadora Souza Rodrigues
7
Cintia Johnston
Cintia Johnston
8
Artur Figueiredo Delgado
Artur Figueiredo Delgado
1 Faculdade de Medicina da Universidade de São Paulo

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Coronavirus disease 2019 (COVID-19) has become an important cause critical care admission worldwide. In the context of newly described multisystem inflammatory syndrome temporally related to SARS-CoV-2 (PIM-TS), the question of liver compromise came into evidence. Our group summarized a case series of 6 critically ill COVID-19 pediatric patients that presented some degree of liver damage, as demonstrated by liver and/or canalicular enzymes elevation, a yet not fully explored characteristic of the infection in the pediatric patient, that may indicate a more severe progression. Observations regarding the role of systemic inflammatory response can be taken from the described cases.

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References

  1. Chao Zhang,Lei Shi,Fu-Sheng Wang (2020). Liver injury in COVID-19: management and challenges.
  2. Elizabeth Whittaker,Alasdair Bamford,Julia Kenny,Myrsini Kaforou,Christine Jones,Priyen Shah,Padmanabhan Ramnarayan,Alain Fraisse,Owen Miller,Patrick Davies,Filip Kucera,Joe Brierley,Marilyn Mcdougall,Michael Carter,Adriana Tremoulet,Chisato Shimizu,Jethro Herberg,Jane Burns,Hermione Lyall,Michael Levin (2020). Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2.
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  13. Xiao-Jing Zhang,Xu Cheng,Zhen-Zhen Yan,Jing Fang,Xiaozhan Wang,Weijun Wang,Zhen-Yu Liu,Li-Jun Shen,Peng Zhang,Pi-Xiao Wang,Rufang Liao,Yan-Xiao Ji,Jun-Yong Wang,Song Tian,Xue-Yong Zhu,Yan Zhang,Rui-Feng Tian,Lin Wang,Xin-Liang Ma,Zan Huang,Zhi-Gang She,Hongliang Li (2018). An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia–reperfusion injury.
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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

werther_brunow_de_carvalho. 2020. \u201cLiver Damage in Pediatric Critically Ill COVID-19 Patients: Brazilian Case-Series\u201d. Global Journal of Medical Research - F: Diseases GJMR-F Volume 20 (GJMR Volume 20 Issue F12): .

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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December 14, 2020

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Coronavirus disease 2019 (COVID-19) has become an important cause critical care admission worldwide. In the context of newly described multisystem inflammatory syndrome temporally related to SARS-CoV-2 (PIM-TS), the question of liver compromise came into evidence. Our group summarized a case series of 6 critically ill COVID-19 pediatric patients that presented some degree of liver damage, as demonstrated by liver and/or canalicular enzymes elevation, a yet not fully explored characteristic of the infection in the pediatric patient, that may indicate a more severe progression. Observations regarding the role of systemic inflammatory response can be taken from the described cases.

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Liver Damage in Pediatric Critically Ill COVID-19 Patients: Brazilian Case-Series

Werther Brunow De Carvalho
Werther Brunow De Carvalho
Michele Luglio
Michele Luglio
Uenis Tannuri
Uenis Tannuri
Maria Fernanda Badue Pereira
Maria Fernanda Badue Pereira
Isadora Souza Rodrigues
Isadora Souza Rodrigues
Cintia Johnston
Cintia Johnston
Artur Figueiredo Delgado
Artur Figueiredo Delgado

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