Studies on the using of 2-Phenoxyethanol as an Alternative to Thiomersal as a Preservative in Foot-and-Mouth Disease Vaccine

Studies on the using of 2-Phenoxyethanol as an Alternative to Thiomersal as a Preservative in Foot-and-Mouth Disease Vaccine

Hany I Abu-Elnaga

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Sonia A Rizk

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Hind M Daoud

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Akram Z Hegazy

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Walaa S Shabana

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σ Veterinary Serum and Vaccine Research Institute

Studies on the using of 2-Phenoxyethanol as an Alternative to Thiomersal as a Preservative in Foot-and-Mouth Disease Vaccine

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Abstract

The progress in foot-and-mouth disease (FMD) vaccine production directed primarily towards the safety of the vaccine, purity of the antigen, selection of proper additives, as adjuvant and preservative. Thimerosal (Merthiolate) has been used as a preservative since 1930. Nevertheless, it is important to note that Thiomersal itself proved to be very toxic because it contains mercury. Hence, the current article discussed the cause and the prevention measures of the pyrogen-free colored sediment that might appear in the vaccine formula. Where the etiology might appear in the biological product was approached and solved. Besides, 2-phenoxyethanol examined as an alternative preservative in FMD vaccine, where it showed safety and efficacy as substitutional.

References

19 Cites in Article

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Hany I Abu-Elnaga. 2019. \u201cStudies on the using of 2-Phenoxyethanol as an Alternative to Thiomersal as a Preservative in Foot-and-Mouth Disease Vaccine\u201d. Global Journal of Medical Research - G: Veterinary Science & Medicine GJMR-G Volume 19 (GJMR Volume 19 Issue G1): .

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GJMR Volume 19 Issue G1
Pg. 1- 5

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-G Classification: NLMC Code: WA 360

Submission ReceivedDecember 14, 2018
Peer Review Double Blind
Handling Editor
Accepted January 5, 2019
Published January 15, 2019

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v1.2

Issue date

March 9, 2019

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Article Matrices

Total Score: 105

Country: Egypt

Subject: Global Journal of Medical Research - G: Veterinary Science & Medicine

Authors: Hany I Abu-Elnaga, Sonia A Rizk, Hind M Daoud, Akram Z Hegazy, Walaa S Shabana (PhD/Dr. count: 0)

View Count (all-time): 141

Total Views (Real + Logic): 2811

Total Downloads (simulated): 1388

Publish Date: 2019 03, Sat

Monthly Totals (Real + Logic):

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Total Views: 2811

Total Downloads: 1388

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