Stem Cell Therapy in Multiple Myeloma

Stem Cell Therapy in Multiple Myeloma

Roshna P P

Contact

Sreejith K

Contact

Government Medical College

Article Fingerprint

ReserarchID

PS10H

Stem Cell Therapy in Multiple Myeloma Banner

AI TAKEAWAY

Connecting with the Eternal Ground

Abstract

Multiple myeloma is a haematogical malignancy caused by abnormality of plasma cells characterized by (a) hypercalcemia, (b) renal insufficiency or failure, (c)bone pain and abnormal bone radiographs, (d) anemia and (e) a monoclonal protein in urine or serum or both. It begins in the form known as monoclonal gammopathy of undetermined significance (MGUS) and progresses to asymptomatic myeloma and then lastly to symptomatic myeloma. The three main domains in the understanding of Pathophysiology are cytokines and cell signaling, bone Marrow Microenvironment and cell Cycle. Bifunctional alkylating agents like Melphalan and cyclophosphamide are considered as standard therapy for multiple myeloma. Patients who are chosen for stem cell transplantation can be treated with Lenalidomide, an immunomodulatory agent and an aminosustituted variant of Thalidomide. It is given along with dexamethas one. In stem cell therapy, the patients receive stem cells intravenously similar to the blood transfusion and this phase takes 1-5 hours. After entering the blood stream through a process called engraftment, the stem cell produce new WBCs, RBCs and platelets. The immune rejection of donor cells by the host immune system is a major drawback of transplantation. Stem cell therapy in multiple myeloma is very effective and should be opted as one among the best for both older patients and patients younger than 65 years.

References

19 Cites in Article

Reference Format

M Sundarjagannath (2008). Pathophysiogical Under spinnings of Multiple Myeloma progression.
Evangelos Terpos (2018). Pathogenesis of bone disease in multiple myeloma: from bench to bedside.
Lynda Campbell (1999). Conventional Cytogenetics in Myeloma.
Robert Kyle (2009). Treatment of Multiple Myeloma: A comprehensive Review.
Christian Gerecke (2016). The Diagnosis and treatment of multiple myeloma.
Leonard Naymagon,Maher Abdul-Hay (2016). Novel agents in the treatment of multiple myeloma: a review about the future.
Ajay Gupta,Lalit Kumar (2011). Evolving role of high dose stem cell therapy in multiple myeloma.
Laurent Garderet (2016). Upfront autologous stem cell transplantation for newly diagnosed elderly multiple myeloma patients: a prospective multicenter study.
Yin (2018). Allogenic stem cell transplantation for multiple myeloma: a systematic review and meta-analysis frok 2007 to 2017.
Reddy Stem cell therapy for cancer.
R Zeiser,H Bertz,A Spyridonidis,L Houet,J Finke (2004). Donor lymphocyte infusions for multiple myeloma: clinical results and novel perspectives.
T Jeevani Stem cell transplantation-Types. Risks and Benefits.
Shaji Kumar (2009). Stem cell transplantation for multiple myeloma.
William Matsui,Ivan Borrello,Constantine Mitsiades (2012). Autologous Stem Cell Transplantation and Multiple Myeloma Cancer Stem Cells.
G Shernan,Holtan (2006). Timing of autologous stem cell transplantation from last chemotherapy affects lymphocyte collection and survival in non-Hodkin lymphoma.
A Morie,Gertz (2014). How we manage autologous stem cell transplantation for patients with multiple myeloma.
W Mark,Owdell (1997). Less is more": The Role of Purging in Hematopoietic Stem Cell Transplantation.
Anne Lennard (2001). Stem cell transplantation.
(2012). The benefits and risks of stem cell technology.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Roshna P P. 2018. \u201cStem Cell Therapy in Multiple Myeloma\u201d. Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 18 (GJMR Volume 18 Issue C1).

More Citation Formats

Select Citation Style:

Download Citation

GJMR Volume 18 Issue C1

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

Not Found

Classification

GJMR-C Classification NLMC Code: WH 540

Submission ReceivedDecember 14, 2017
Peer Review Double Blind
Handling Editor
Accepted January 2, 2018
Published January 15, 2018

Version of record

v1.2

Issue date

July 30, 2018

Language

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Score: 102

Country: India

Subject: Global Journal of Medical Research - C: Microbiology & Pathology

Authors: Roshna P P, Sreejith K (PhD/Dr. count: 0)

View Count (all-time): 227

Total Views (Real + Logic): 3130

Total Downloads (simulated): 1478

Publish Date: 2018 07, Mon

Monthly Totals (Real + Logic):

Month 1: 60 views
Month 2: 58 views
Month 3: 27 views
Month 4: 46 views
Month 5: 47 views
Month 6: 37 views
Month 7: 57 views
Month 8: 37 views
Month 9: 47 views
Month 10: 40 views
Month 11: 31 views
Month 12: 35 views
Month 13: 44 views
Month 14: 30 views
Month 15: 31 views
Month 16: 23 views
Month 17: 34 views
Month 18: 10 views
Month 19: 27 views
Month 20: 17 views
Month 21: 34 views
Month 22: 35 views
Month 23: 35 views
Month 24: 15 views
Month 25: 42 views
Month 26: 35 views
Month 27: 28 views
Month 28: 33 views
Month 29: 26 views
Month 30: 37 views
Month 31: 31 views
Month 32: 32 views
Month 33: 18 views
Month 34: 36 views
Month 35: 32 views
Month 36: 15 views
Month 37: 15 views
Month 38: 17 views
Month 39: 32 views
Month 40: 29 views
Month 41: 47 views
Month 42: 38 views
Month 43: 26 views
Month 44: 28 views
Month 45: 24 views
Month 46: 44 views
Month 47: 27 views
Month 48: 13 views
Month 49: 28 views
Month 50: 27 views
Month 51: 30 views
Month 52: 33 views
Month 53: 22 views
Month 54: 33 views
Month 55: 42 views
Month 56: 31 views
Month 57: 31 views
Month 58: 25 views
Month 59: 25 views
Month 60: 36 views
Month 61: 44 views
Month 62: 22 views
Month 63: 25 views
Month 64: 38 views
Month 65: 19 views
Month 66: 16 views
Month 67: 33 views
Month 68: 20 views
Month 69: 28 views
Month 70: 23 views
Month 71: 45 views
Month 72: 39 views
Month 73: 16 views
Month 74: 27 views
Month 75: 31 views
Month 76: 26 views
Month 77: 46 views
Month 78: 17 views
Month 79: 21 views
Month 80: 41 views
Month 81: 26 views
Month 82: 29 views
Month 83: 13 views
Month 84: 36 views
Month 85: 35 views
Month 86: 21 views
Month 87: 41 views
Month 88: 20 views
Month 89: 41 views
Month 90: 33 views
Month 91: 52 views
Month 92: 53 views
Month 93: 62 views

Total Views: 3130

Total Downloads: 1478

2026 Trends

Our website is actively being updated, and changes may occur frequently. Please clear your browser cache if needed. For feedback or error reporting, please email [email protected]