Biochemical Identifiers of Postmortem Time Interval on Autopsy of Albino Rats Versus Physiological One

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Mahmoud M. El alfy
Mahmoud M. El alfy PhD of forensic medicine and toxicology
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El-hadidy G. Mona
El-hadidy G. Mona
α Mansoura University Mansoura University

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Biochemical Identifiers of Postmortem Time Interval on Autopsy of Albino Rats Versus Physiological One

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Abstract

Post mortem time interval is still controversial point as no definitive markers estimate successful time since death even there are many studies on human or experimental models investigate physical, biochemical and molecular marker fôr identification periods of time elapsed after death. After death, no system or organ work in integrity mannar, body loss its immune defence and no elimination of breakdown of each cells which could be explain elevation of certain biochemical in serum of dead animal. In this study, we induced brain stem death induced in albino male rat and take heart blood at different time point for analysis of PH, Ast, Alt, lactate dehydrogenase, creatinine, s-fas and tnfa. It was found that PH reduced while serum lactate dehydrogenase was increased in time dependent manner. Notably, s-fas and tnfa increase in dependent manner until last time point. But AST, AlT, BUN and creatinine shown no change except little increase in last time point. On conclusion group of biochemical could be used in estimation of postmortem time interval for each time point.

References

21 Cites in Article
  1. Sara Zapico,T Sofía,Paula Menéndez,Núñez (2014). Cell death proteins as markers of early postmortem interval Cell.
  2. Alberto Amadasi,Annalisa Cappella,Cristina Cattaneo,Pacifico Cofrancesco,Lucia Cucca,Daniele Merli,Chiara Milanese,Andrea Pinto,Antonella Profumo,Valentina Scarpulla,Emanuela Sguazza (2017). Determination of the post mortem interval in skeletal remains by the comparative use of different physico-chemical methods: Are they reliable as an alternative to 14C?.
  3. Kumar Sharmaa Ruchi,Gaurb Rakesh,J Garga (2015). Various methods for the estimation of the post mortem interval from Calliphoridae.
  4. Mathur Ashima,Y (2011). An overview of methods used for estimation of time since death journal of.
  5. A Donaldson,I Lamont (2013). Biochemistry Changes That Occur after Death: Potential Markers for Determining Post-Mortem Interval.
  6. Nidhi Sachdeva,**yashoda Rani (2011). ***Ritu Singh and Atul Murar Estimation of Post-Mortem Interval from the Changes in Vitreous.
  7. Costa Isabel,Carvalho Félix,Magalhães Teresa,Pinho Paula Guedes De,Silvestre Ricardo,Dinis-Oliveira Ricardo,Jorge (1443). Promising blood-derived biomarkers for estimation of the postmortem interval †.
  8. Zapico C S 1,S Menéndez,P Núñez (2014). Cell death proteins as markers of early post mortem interval.
  9. Kikuchi K 1,K Kawahara,K Biswas,T Ito,S Tancharoen,N Shiomi,Y Koda,F Matsuda,Y Morimoto,Y Oyama,K Takenouchi,N Miura,N Arimura,Y Nawa,S Arimura,M Jie,B Shrestha,M Iwata,K Mera,H Sameshima,Y Ohno,R Maenosono,Y Tajima,H Uchikado,T Kuramoto,K Nakayama,M Shigemori,Y Yoshida,T Hashiguchi,I Maruyama (2010). HMGB1: A new marker for estimation of the postmortem interval.
  10. S1 Zhang,S Cao,T Wang,B Yan,Y Lu,Y Zhao (2014). Modified brain death model for rats.
  11. R Mole (1948). Fibrinolysin and the fluidity of the blood post mortem.
  12. Sanae Takeichi,Choei Wakasugi,Ichiro Shikata (1985). Fluidity of cadaveric blood after sudden death: Part II.
  13. W Sawyer,D Steup,B Martin,R Forney (1988). Cardiac blood pH as a possible indicator of postmortem interval.
  14. B Dent,S Forbes,B Stuart (2004). Review of Human Decomposition Processes in Soil.
  15. Alessandra Calábria Baxmann,Marion Souza Ahmed,Natália,Cristina Marques,Viviane Barcellos Menon,* Aparecido,Bernardo Pereira,Gianna Mastroianni Kirsztajn,Ita Pfeferman,Heilberg (2008). Influence of Muscle Mass and Physical Activity on Serum and Urinary Creatinine and Serum Cystatin CClin.
  16. Caviedes-Bucheli J1 Avendaño,N Gutierrez,R Hernández,S Moreno,G Romero,M,Muñoz Hr (2006). Quantification of lactate-dehydrogenase and cell viability in postmortem human dental pulp.
  17. M1 Diop,D2 Watier,Py3 ; Masson,R5 Amara,T6 Grard (2016). Lencel P7F Assessment of freshness and freeze-thawing of sea bream fillets (Sparus aurata) by a cytosolic enzyme: Lactate dehydrogenase.
  18. Tomasz Gos,Stefan Raszeja (1993). Postmortem activity of lactate and malate dehydrogenase in human liver in relation to time after death.
  19. Beer Ronny,Franz Gerhard,Schopf Marion,Reindl Markus,Zeiger Bernhard,Schmutzhard Erich,Poewe Werner,Kampfl Andreas (2000). Expression of Fas and Fas Ligand After Experimental Traumatic Brain Injury in the Rat Journal of Cerebral Blood Flow and.
  20. J1 Qiu,M Whalen,P Lowenstein,G Fiskum,B Fahy,R Darwish,B Aarabi,J Yuan,M Moskowitz (2002). Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans.
  21. Badr Rawia,Badr Hatem,Aly Nabil,Ibrahim Abdelwahab (2013). Serum sFas, TNF-α and Bcl2 expression following Traumatic Brain Injury egyptian.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Mahmoud M. El alfy. 2018. \u201cBiochemical Identifiers of Postmortem Time Interval on Autopsy of Albino Rats Versus Physiological One\u201d. Global Journal of Medical Research - G: Veterinary Science & Medicine GJMR-G Volume 18 (GJMR Volume 18 Issue G1): .

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-G Classification: NLMC Code: QW 70
Version of record

v1.2

Issue date

June 6, 2018

Language
en
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Post mortem time interval is still controversial point as no definitive markers estimate successful time since death even there are many studies on human or experimental models investigate physical, biochemical and molecular marker fôr identification periods of time elapsed after death. After death, no system or organ work in integrity mannar, body loss its immune defence and no elimination of breakdown of each cells which could be explain elevation of certain biochemical in serum of dead animal. In this study, we induced brain stem death induced in albino male rat and take heart blood at different time point for analysis of PH, Ast, Alt, lactate dehydrogenase, creatinine, s-fas and tnfa. It was found that PH reduced while serum lactate dehydrogenase was increased in time dependent manner. Notably, s-fas and tnfa increase in dependent manner until last time point. But AST, AlT, BUN and creatinine shown no change except little increase in last time point. On conclusion group of biochemical could be used in estimation of postmortem time interval for each time point.

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Biochemical Identifiers of Postmortem Time Interval on Autopsy of Albino Rats Versus Physiological One

Mahmoud M. El alfy
Mahmoud M. El alfy Mansoura University
El-hadidy G. Mona
El-hadidy G. Mona

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