An Innovative Gateway to Deliver Nanosized Atorvastatin by Bio-Flexy Film Approach

An Innovative Gateway to Deliver Nanosized Atorvastatin by Bio-Flexy Film Approach

Kirti Singh

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N. V. Satheesh Madhav

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An Innovative Gateway to Deliver Nanosized Atorvastatin by Bio-Flexy Film Approach

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Abstract

Atorvastatin is an antihyperlipidemic drug which is widely used to treat hyperlipidemia and lower the cholesterol level in the body, but atorvastatin has low bioavailability due to high intestinal clearance and first-pass metabolism. The main objective of our research work was to develop a formulation to increase the therapeutic efficacy of the drug. A bio-polymer was isolated from a natural edible source Coriandrum sativum and was subjected for screening its filmability and adhesivity. Atorvastatin was nanosized using a novel method and using the bio-polymer and other co-processing agents five bio-flexy films of different ratios (i.e. 1:1, 1:2, 1:3, 1:4, 1:5) were formulated. The isolated bio-polymer was subjected to various analytical parameters. The drug-excipient compatibility study was performed using UV and TLC method. The formulated bio-flexy films were evaluated for various parameters like weight, thickness, content uniformity, surface pH, folding endurance, and in-vitro drug permeation. The formulation AC2 (containing 1:2 bio-polymer) was found to be the best formulation having R 2 value 0.9989 with zero order as best fit model.

References

12 Cites in Article

Reference Format

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

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Not applicable for this article.

How to Cite This Article

Kirti Singh. 2019. \u201cAn Innovative Gateway to Deliver Nanosized Atorvastatin by Bio-Flexy Film Approach\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 18 (GJMR Volume 18 Issue B5).

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GJMR Volume 18 Issue B5

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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Classification

GJMR-B Classification NLMC Code: QV 785

Submission ReceivedDecember 6, 2017
Peer Review Double Blind
Handling Editor
Accepted January 4, 2018
Published January 15, 2018

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v1.2

Issue date

January 4, 2019

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Article Matrices

Total Score: 102

Country: India

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Kirti Singh, N. V. Satheesh Madhav (PhD/Dr. count: 0)

View Count (all-time): 172

Total Views (Real + Logic): 2809

Total Downloads (simulated): 1412

Publish Date: 2019 01, Fri

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Total Views: 2809

Total Downloads: 1412

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