Correlation of Lymph Node Density and Recurrence in Carcinoma Penis: A Perspective on Optimal Management and Unmet Needs from a Tertiary Care Centre

Introduction: Penile carcinoma is a devastating urological neoplasm in which the most assertive prognostic variable is the presence of lymph node involvement. Multiple studies in the current literature have shown that the number of positive lymph nodes predict recurrence free survival (RFS) and overall survival (OS). The objective of this present retrospective analysis is to authenticate the use of LND as a predictor of RFS and OS after ILND. Methods: Our institutional penile cancer database was analyzed for patients who underwent ILND from January 2000 to May 2008. Survival analysis was performed using the Kaplan-Meier method to determine RFS and OS. Two-sided p values

References

29 Cites in Article

Reference Format

A Ornellas,Seixas De Moraes,J (1991). Analyses of 200 lymphadenectomies in patients with penile carcinoma.
R Ravi (1993). Correlation between the Extent of Nodal Involvement and Survival following Groin Dissection for Carcinoma of the Penis.
Y Zhu,Ye Yao,X Zhang,S Dai,B Zhang,H (2011). New Nstaging system of penile cancer provides a better reflection of prognosis.
(2009). UICC. TNM-Classification of Malignant Tumours.
Giorgio Pizzocaro,Ferran Algaba,Simon Horenblas,Eduard Solsona,Silvia Tana,Hein Van Der Poel,Nicholas Watkin (2010). EAU Penile Cancer Guidelines 2009.
Robert Svatek,Mark Munsell,Jordan Kincaid,Paul Hegarty,Joel Slaton,J Busby,Kris Gaston,Philippe Spiess,Lance Pagliaro,Pheroze Tamboli,Curtis Pettaway (2009). Association Between Lymph Node Density and Disease Specific Survival in Patients With Penile Cancer.
Jian-Ye Liu,Yong-Hong Li,Zhi-Ling Zhang,Kai Yao,Yun-Lin Ye,Dan Xie,Hui Han,Zhou-Wei Liu,Zi-Ke Qin,Fang-Jian Zhou (2013). The risk factors for the presence of pelvic lymph node metastasis in penile squamous cell carcinoma patients with inguinal lymph node dissection.
Yao Zhu,Cheng-Yuan Gu,Ding-Wei Ye (2014). Population-Based Assessment of the Number of Lymph Nodes Removed in the Treatment of Penile Squamous Cell Carcinoma.
John Stein,Jie Cai,Susan Groshen,Donald Skinner (2003). Risk Factors for Patients With Pelvic Lymph Node Metastases Following Radical Cystectomy With En Bloc Pelvic Lymphadenectomy: The Concept of Lymph Node Density.
Wassim Kassouf,Dan Leibovici,Mark Munsell,Colin Dinney,H Grossman,Ashish Kamat (2006). Evaluation of the Relevance of Lymph Node Density in a Contemporary Series of Patients Undergoing Radical Cystectomy.
Li Yao,K Chen,P Zou,Z,Qin Liu,Z (2014). Diseasespecific survival after radical lymphadenectomy for penile cancer: prediction by lymph node count and density.
Giovanni Lughezzani,Mario Catanzaro,Tullio Torelli,Luigi Piva,Davide Biasoni,Silvia Stagni,Andrea Necchi,Patrizia Giannatempo,Daniele Raggi,Elena Fare',Maurizio Colecchia,Giorgio Pizzocaro,Roberto Salvioni,Nicola Nicolai (2015). Relationship between lymph node ratio and cancer‐specific survival in a contemporary series of patients with penile cancer and lymph node metastases.
R Svatek,M Munsell,Kincaid Hegarty,P Slaton,J Busby,J (2009). Association between lymph node density and disease specific survival in patients with penile cancer.
Y Zhu,C Gu,D Ye (2013). Validation of the prognostic value of lymph node ratio in patients with penile squamous cell carcinoma: a populationbased study.
Madhu Mazumdar,Jill Glassman (2000). Categorizing a prognostic variable: review of methods, code for easy implementation and applications to decision‐making about cancer treatments.
Jun Kasuga,Takashi Kawahara,Daiji Takamoto,Sachi Fukui,Takashi Tokita,Tomoyuki Tadenuma,Masaki Narahara,Syusei Fusayasu,Hideyuki Terao,Koji Izumi,Hiroki Ito,Yusuke Hattori,Jun-Ichi Teranishi,Takeshi Sasaki,Kazuhide Makiyama,Yasuhide Miyoshi,Masahiro Yao,Yasushi Yumura,Hiroshi Miyamoto,Hiroji Uemura (2016). Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer.
Joost Leijte,Maarten Gallee,Ninja Antonini,Simon Horenblas (2008). Evaluation of Current TNM Classification of Penile Carcinoma.
Durgatosh Pandey,Vikash Mahajan,R Kannan (2006). Prognostic factors in node-positive carcinoma of the penis.
C Protzel,A Alcaraz,S Horenblas,G Pizzocaro,A Zlotta,O Hakenberg (2009). Lymphadenectomy in the surgical management of penile cancer.
Durgatosh Pandey,Vikash Mahajan,R Kannan (2006). Prognostic factors in node-positive carcinoma of the penis.
Wassim Kassouf,Dan Leibovici,Mark Munsell,Colin Dinney,H Grossman,Ashish Kamat (2006). Evaluation of the Relevance of Lymph Node Density in a Contemporary Series of Patients Undergoing Radical Cystectomy.
Ganesh Palapattu,Mohamad Allaf,Bruce Trock,Jonathan Epstein,Patrick Walsh (2004). PROSTATE SPECIFIC ANTIGEN PROGRESSION IN MEN WITH LYMPH NODE METASTASES FOLLOWING RADICAL PROSTATECTOMY: RESULTS OF LONG-TERM FOLLOWUP.
J Stein,J Cai,S Groshen,D Skinner (2003). Risk factors for patients with pelvic lymph node metastases following radical cystectomy with en bloc pelvic lymphadenectomy: concept of lymph node density.
Johnson Hsiao,W,Delman,Jani Brawley,O Master,V (2010). Extensive inguinal lymphadenectomy improves overall 5-year survival in penile cancer patients: results from the Surveillance, Epidemiology, and End Results program.
Oliver Hakenberg,Eva Compérat,Suks Minhas,Andrea Necchi,Chris Protzel,Nick Watkin (2015). EAU Guidelines on Penile Cancer: 2014 Update.
Giorgio Pizzocaro,Nicola Nicolai,Angelo Milani (2009). Taxanes in Combination with Cisplatin and Fluorouracil for Advanced Penile Cancer: Preliminary Results.
Edouard Trabulsi,Jean Hoffman-Censits (2010). Chemotherapy for Penile and Urethral Carcinoma.
Lance Pagliaro,Dallas Williams,Danai Daliani,Michael Williams,William Osai,Michael Kincaid,Sijin Wen,Peter Thall,Curtis Pettaway (2010). Neoadjuvant Paclitaxel, Ifosfamide, and Cisplatin Chemotherapy for Metastatic Penile Cancer: A Phase II Study.
Fig (null). Fig. 1. Overall survival and progression-free survival of patients with stage IIB–IIIB ovarian cancer (Kaplan–Meier method).

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How to Cite This Article

Yashasvi Singh. 2018. \u201cCorrelation of Lymph Node Density and Recurrence in Carcinoma Penis: A Perspective on Optimal Management and Unmet Needs from a Tertiary Care Centre\u201d. Global Journal of Medical Research - K: Interdisciplinary GJMR-K Volume 18 (GJMR Volume 18 Issue K7): .

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GJMR Volume 18 Issue K7
Pg. 17- 23

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-K Classification: NLMC Code: WJ 140

Submission ReceivedDecember 13, 2017
Peer Review Double Blind
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Accepted January 1, 2018
Published January 15, 2018

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Total Score: 125

Country: India

Subject: Global Journal of Medical Research - K: Interdisciplinary

Authors: Rajeev T.P, Sasanka Kumar Barua, Yashasvi Singh, Debanga Sarma, Saumar Jyoti Baruah, Puskal Kumar Bagchi, Dr. Dijesh Damodaran, Pranab kumar kaman, Dr. Manash Pratim Kashyap, Dr. Dijesh Damodaran (PhD/Dr. count: 3)

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