Chronic Inflammation Induced Immunosuppression Tumor Microenvironment of Oral Cancer

Chronic Inflammation Induced Immunosuppression Tumor Microenvironment of Oral Cancer

Shrihari T.G

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Ramesh DNSV

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Chronic Inflammation Induced Immunosuppression Tumor Microenvironment of Oral Cancer

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Abstract

Oral Cancer is a wound that do not heal is a complex disease consists of heterogeneous tissue in their tumor microenvironment. Oral cancer accounts eighth most Common Cancer worldwide. Chronic inflammatory mediators released from immune cells in tumor microenvironment of oral cancer such as macrophages, T lymphocytes, dendritic cells, Natural killer cells release cytokines, Chemokine’s and growth factors helps in generation of myeloid derived suppressor cells. Myeloid derived suppressor cells are derived from myeloid progenitor cells of bone marrow secretes inflammatory mediators iNOS, arginase-1, PGE2,IL-10 and IL-4 suppresses adaptive and innate immunity by interacting with macrophages, T-cells, Natural killer cells and dendritic cells favours pro-tumoral activity by activating transcriptional factors (NF-KB,STAT -3,HIF) further progress in to oral cancer. Myeloid derived suppressor cells reduces T cell activation and function by Arginase-1, iNOS, peroxynitrate over expression and cysteine depletion.

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No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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How to Cite This Article

Shrihari T.G. 2016. \u201cChronic Inflammation Induced Immunosuppression Tumor Microenvironment of Oral Cancer\u201d. Global Journal of Medical Research - J: Dentistry & Otolaryngology GJMR-J Volume 16 (GJMR Volume 16 Issue J2).

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Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-J Classification NLMC Code: WU 158

Submission ReceivedDecember 10, 2015
Peer Review Double Blind
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Accepted January 1, 2016
Published January 15, 2016

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October 8, 2016

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Total Score: 102

Country: India

Subject: Global Journal of Medical Research - J: Dentistry & Otolaryngology

Authors: Shrihari T.G, Ramesh DNSV (PhD/Dr. count: 0)

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