Systemic and Local Immune Response to H. Pylori Infection and their Correlation with the Degree of Antral and Duodenal Inflammation

Systemic and Local Immune Response to H. Pylori Infection and their Correlation with the Degree of Antral and Duodenal Inflammation

Magbri A MD

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Awad Magbri

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Fiona Stevens

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α Pine (Partners in Nephrology and Endocrinology)

Systemic and Local Immune Response to H. Pylori Infection and their Correlation with the Degree of Antral and Duodenal Inflammation

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Abstract

Design, setting, participants & measurements: One hundred and eight patients presented to the University College Hospital Galway, Ireland (UCHG) with upper gastro-intestinal symptoms were included in the study. There were 52 males with age range 18-82 years, mean age 49 years, and 56 females, age range 20-83 years, mean age 52 years. They were grouped according to the endoscopic findings into 4 groups (i) Duodenal Ulcer (DU), (ii) Gastric Ulcer (GU), (iii) Gastritis (GS), & (iv) Non-Ulcer Dyspepsia (NUD). Five milliliter of venous blood was taken in a sterile plain tube; the serum was separated and stored at -70 C0 for ELISA assay. Endoscopy was carried out and at least 4 biopsies were obtained, 2 from the antrum and 2 from the first part of the duodenum (duodenal bulb). One biopsy each from the antrum and duodenum was transferred immediately into a sterile container containing 2 mL of RPMI 1640. The other biopsy specimens one from the antrum and one from the duodenum were processed for histological examination. The serum IgG antibodies to H. pylori and local IgA and IgG were measured by an ELISA test.

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No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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How to Cite This Article

Magbri A MD. 2016. \u201cSystemic and Local Immune Response to H. Pylori Infection and their Correlation with the Degree of Antral and Duodenal Inflammation\u201d. Global Journal of Medical Research - F: Diseases GJMR-F Volume 16 (GJMR Volume 16 Issue F3): .

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GJMR Volume 16 Issue F3
Pg. 21- 26

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-F Classification: NLMC Code: WD 308

Submission ReceivedDecember 14, 2015
Peer Review Double Blind
Handling Editor
Accepted January 3, 2016
Published January 15, 2016

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v1.2

Issue date

July 4, 2016

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Article Matrices

Total Score: 132

Country: United States

Subject: Global Journal of Medical Research - F: Diseases

Authors: Awad Magbri, Fiona Stevens (PhD/Dr. count: 0)

View Count (all-time): 129

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Publish Date: 2016 07, Mon

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Total Views: 3704

Total Downloads: 1875

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