A Diagnostic Challenge in a Patient with Intractable Nausea and Vomiting: A Case of Systemic Amyloidosis

A Diagnostic Challenge in a Patient with Intractable Nausea and Vomiting: A Case of Systemic Amyloidosis

Ali Ghani

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Naveed Ali

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Apurva Gandhi

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Ritesh Rampure

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Herbert E. Auerbach DO

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A Diagnostic Challenge in a Patient with Intractable Nausea and Vomiting: A Case of Systemic Amyloidosis

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Abstract

Amyloidosis is a rare disorder caused by deposition of amyloid fibrils in various tissues causing structural and functional defects. Depending upon organs involved, it may be categorized as localized or systemic. Systemic amyloidosis involves multiple organs where some organs are affected more commonly than others. Diagnosis is often challenging as in a 76-yearsold female described here who presented with intractable nausea and vomiting. Clinical course was complicated because of simultaneous presence of peptic ulcer disease and hypothyroidism. Involvement of multiple systems including gastrointestinal tract, thyroid, liver, heart and kidneys was seen, and diagnosis was achieved after renal biopsy showing Congo red staining and apple green birefringence. Gastric and thyroid infiltration by amyloidosis are extremely rare occurrences described very infrequently in the literature. However, to our knowledge, involvement of both organs in a single patient has not been reported in the literature.

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No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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How to Cite This Article

Ali Ghani. 2016. \u201cA Diagnostic Challenge in a Patient with Intractable Nausea and Vomiting: A Case of Systemic Amyloidosis\u201d. Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 15 (GJMR Volume 15 Issue C5).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

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GJMR-C Classification NLMC Code: WI 146

Submission ReceivedDecember 6, 2014
Peer Review Double Blind
Handling Editor
Accepted January 1, 2015
Published January 15, 2015

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January 6, 2016

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Article Matrices

Total Score: 135

Country: United States

Subject: Global Journal of Medical Research - C: Microbiology & Pathology

Authors: Naveed Ali, Ali Ghani, Apurva Gandhi, Ritesh Rampure, Herbert E. Auerbach DO (PhD/Dr. count: 0)

View Count (all-time): 179

Total Views (Real + Logic): 4066

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Publish Date: 2016 01, Wed

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Total Views: 4066

Total Downloads: 1998

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