FLUOXETINE BIOEQUIVALENCE STUDY: QUANTIFICATION OF FLUOXETINE BY LIQUID CHROMATOGRAPHY COUPLED TO MASS SPECTROMETRY

FLUOXETINE BIOEQUIVALENCE STUDY: QUANTIFICATION OF FLUOXETINE BY LIQUID CHROMATOGRAPHY COUPLED TO MASS SPECTROMETRY

Article ID

B7G43

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FLUOXETINE BIOEQUIVALENCE STUDY: QUANTIFICATION OF FLUOXETINE BY LIQUID CHROMATOGRAPHY COUPLED TO MASS SPECTROMETRY

Dr.Luciana Fernandes Duarte

Lara Cristina Silva

Moiss L. P. Vanunci

Tatiane A. M. Stein e Marina M. Nakamura

DOI

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Abstract

A liquid chromatography method was developed and validated for the determination of fluoxetine in human plasma using paroxetine as internal standard. The drugs were extracted from plasma by liquid-liquid extraction and separated isocratically on a C 18 analytical column, with water:acetonitrile as mobile phase, run at a flow rate of 0.20 mL/min. The method was linear in the range of 0.2-50 ng/mL and demonstrated acceptable results for the precision, accuracy and stability studies. The method was successfully applied for the bioequivalence study of two tablet formulations of fluoxetine 20 mg after single oral dose administration to healthy human volunteers.

FLUOXETINE BIOEQUIVALENCE STUDY: QUANTIFICATION OF FLUOXETINE BY LIQUID CHROMATOGRAPHY COUPLED TO MASS SPECTROMETRY

A liquid chromatography method was developed and validated for the determination of fluoxetine in human plasma using paroxetine as internal standard. The drugs were extracted from plasma by liquid-liquid extraction and separated isocratically on a C 18 analytical column, with water:acetonitrile as mobile phase, run at a flow rate of 0.20 mL/min. The method was linear in the range of 0.2-50 ng/mL and demonstrated acceptable results for the precision, accuracy and stability studies. The method was successfully applied for the bioequivalence study of two tablet formulations of fluoxetine 20 mg after single oral dose administration to healthy human volunteers.

Authors

Dr.Luciana Fernandes Duarte

Lara Cristina Silva

Moiss L. P. Vanunci

Tatiane A. M. Stein e Marina M. Nakamura

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dr.luciana_fernandes_duarte. 1970. “. Unknown Journal GJMR Volume 10 (GJMR Volume 10 Issue 2): .

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GJMR Volume 10 Issue 2
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Submission Received April 11, 2010
Accepted May 2, 2010
Published May 15, 2010

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Total Score: 109

Country: Unknown

Subject: Uncategorized

Authors: Dr.Luciana Fernandes Duarte, Lara Cristina Silva, Moiss L. P. Vanunci, Tatiane A. M. Stein e Marina M. Nakamura (PhD/Dr. count: 1)

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