FLUOXETINE BIOEQUIVALENCE STUDY: QUANTIFICATION OF FLUOXETINE BY LIQUID CHROMATOGRAPHY COUPLED TO MASS SPECTROMETRY

Dr.Luciana Fernandes Duarte

FLUOXETINE BIOEQUIVALENCE STUDY: QUANTIFICATION OF FLUOXETINE BY LIQUID CHROMATOGRAPHY COUPLED TO MASS SPECTROMETRY

Dr.Luciana Fernandes Duarte * §

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State University of Campinas

FLUOXETINE BIOEQUIVALENCE STUDY: QUANTIFICATION OF FLUOXETINE BY LIQUID CHROMATOGRAPHY COUPLED TO MASS SPECTROMETRY

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Abstract

A liquid chromatography method was developed and validated for the determination of fluoxetine in human plasma using paroxetine as internal standard. The drugs were extracted from plasma by liquid-liquid extraction and separated isocratically on a C 18 analytical column, with water:acetonitrile as mobile phase, run at a flow rate of 0.20 mL/min. The method was linear in the range of 0.2-50 ng/mL and demonstrated acceptable results for the precision, accuracy and stability studies. The method was successfully applied for the bioequivalence study of two tablet formulations of fluoxetine 20 mg after single oral dose administration to healthy human volunteers.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Dr.Luciana Duarte. 1970. "FLUOXETINE BIOEQUIVALENCE STUDY: QUANTIFICATION OF FLUOXETINE BY LIQUID CHROMATOGRAPHY COUPLED TO MASS SPECTROMETRY". Global Journal of Medical Research GJMR Volume 10 (GJMR Volume 10 Issue 2).

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GJMR Volume 10 Issue 2

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Journal Specifications

Crossref Journal DOI 10.17406/gjmr

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

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Submission ReceivedApril 11, 2010
Peer Review Double Blind
Handling Editor
Accepted May 2, 2010
Published May 15, 2010

Version of record

v1.2

Issue date

August 10, 2010

Language

English

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Article Matrices

Total Score: 149

Country: Unknown

Subject: Global Journal of Medical Research

Authors: Dr.Luciana Fernandes Duarte, Lara Cristina Silva, Moiss L. P. Vanunci, Tatiane A. M. Stein e Marina M. Nakamura (PhD/Dr. count: 1)

View Count (all-time): 223

Total Views (Real + Logic): 4959

Total Downloads (simulated): 132

Publish Date: 2010 05, Sat

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Total Views: 5K

Total Downloads: 132

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