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ReserarchID
PDDTM479RL
Crossref Journal DOI 10.17406/gjmra
Print ISSN 0975-5888
e-ISSN 2249-4618
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In search for specific early ultrasound signs that could indicate an increased risk of hereditary or acquired disorders of the fetus, scientific research confirms the value of exceptional ultrasound findings nuchal translucency (NT). The aim of the study was to determine the predictive value of the diameter of fetal NT in the detection chromosomopathy. The investigation included 317 pregnant women with monofetal pregnancies gestational age of 11 to 14 weeks. The control group consisted of pregnant women in whom amniocentesis was recognized after a neat result of fetal karyotype. We determined the limit of physiological and pathological findings of the value of NT, but we used the diameter of NT that we get in pregnant women with pathological score of amniocentesis as a potentially pathological values. Mean value of NT in the control group was 1.92 ± 0.39 mm, and the group with pathological findings karyotype fetus was 2.49 ± 0.37 mm, which is a statistically significant difference (p 0.05).The probability that a patient with negative findings to be healthy is NT 1.0. NT sensitivity as a marker for chromosomopathy was 1.0. The rate of false positive findings of the 0.026. Specificity of NT as a marker for chromosomopathy is 0.97. The probability that a patient with positive findings NT really be sick is 0.5. Valid findings NT can be considered safe ultrasonographic markers in the assessment of absence chromosomopathy. Pathological finding, given the low positive predictive value of NT must be amended and other prenatal tests before pregnant invasive give advice on prenatal diagnosis.
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