L-lysine Neuro-Dynamic Optimal Control

Dr. Tatiana Ilkova
Dr. Tatiana Ilkova Ph.D.
Dr. Mitko Petrov
Dr. Mitko Petrov
Bulgarian Academy of Sciences Bulgarian Academy of Sciences

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L-lysine Neuro-Dynamic Optimal Control

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Abstract

In this paper Neuro-dynamic programming (NDP) is proposed as an alternative to alleviate the “curse of dimensionality” of the Dynamic programming (DP) for optimal control of a fed-batch fermentation process in the L-lysine production. The most effective and cheapest method for the Llysine biosynthesis (in biological active form) is the microbiological method via a direct fermentation. In this paper an optimization method of the L-lysine production from strain Brevibacterium flavum 22LD is used and that is NDP. The results show that the quality of L-lysine enhances at the end of the process. The proposed method is particularly simple to implement and can be applied for on-line optimization.

References

11 Cites in Article
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  5. N Kaisare,J Lee,J Lee (2003). Simulation based strategy for nonlinear optimal control: application to a microbial cell reactor.
  6. T Ilkova,M Petrov (2008). Dynamic and neurodynamic optimization of a fed-batch fermentation process.
  7. Savas Anastassiadis (2007). L-Lysine Fermentation.
  8. A Soni,R Parker (2002). Fed-batch bioreactor control using a multi-scale model.
  9. D Vlachos,A Mhadeshwar,N Kaisare (2006). Hierarchical multiscale model-based design of experiments, catalysts, and reactors for fuel processing.
  10. J Lee,N Kaisare,J Lee (2006). Choice of approximator and design of penalty function for an approximate dynamic programming based control approach.
  11. Zh Xiong,J Zhang (2005). Neural Network model-based on-line re-optimisation control of fedbatch processes using a modified iterative dynamic programming algorithm.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Dr. Tatiana Ilkova. 1970. \u201cL-lysine Neuro-Dynamic Optimal Control\u201d. Unknown Journal GJMR Volume 11 (GJMR Volume 11 Issue 4).

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Journal Specifications
Version of record

v1.2

Issue date
December 23, 2011

Language
en
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L-lysine Neuro-Dynamic Optimal Control

Dr. Tatiana Ilkova
Dr. Tatiana Ilkova <p>Bulgarian Academy of Sciences</p>
Dr. Mitko Petrov
Dr. Mitko Petrov

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