A Comprehensive Insight into The Development of Animal Models For Obesity Research.

Dr. AMIT GOYAL
Dr. AMIT GOYAL
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Abstract

Obesity, a multifactorial, metabolic disorder, involves complex interaction between genetic and environmental factors. With an alarming increase in the prevalence of obesity worldwide, it has become a major health care burden not just in terms of the increased risk of type 2 diabetes, cardiovascular morbidity, cholelithiasis, arthiritis and certain malignancies, but also in the economic costs to healthcare providers. The great similarity and homology between the genomes of rodents and humans make these animal models an important tool in unraveling the mechanisms involved in the etiology, prevention and treatment of obesity. This review summarizes the various approaches for the induction of obesity in the rodent models via genetic manipulation, hypercaloric diets and neuroendocrine perturbations.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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No ethics committee approval was required for this article type.

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Not applicable for this article.

How to Cite This Article

Dr. AMIT GOYAL. 1970. \u201cA Comprehensive Insight into The Development of Animal Models For Obesity Research.\u201d. Global Journal of Medical Research - G: Veterinary Science & Medicine N/A (GJMR Volume 12 Issue G1).

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords
Animal modelsGenomeHypercaloric dietObesityRodents
  • Submission ReceivedJanuary 1, 2012
  • Peer Review Double Blind
    Handling Editor
  • Accepted January 21, 2012
  • Published February 1, 2012
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v1.2

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A Comprehensive Insight into The Development of Animal Models For Obesity Research.

Dr. AMIT GOYAL
Dr. AMIT GOYAL
  • Submission ReceivedJanuary 1, 2012
  • Peer Review Double Blind
    Handling Editor
  • Accepted January 21, 2012
  • Published February 1, 2012

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