Chronic Ill Effects of Air Pollution in Children: Neurological Derailment

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Dr. Harendra  Kumar
Dr. Harendra Kumar
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Dr. Anita Sharma
Dr. Anita Sharma

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Chronic Ill Effects of Air Pollution in Children:  Neurological Derailment

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Abstract

Exposure to complex mixtures of air pollutants produces inflammation in the upper and lower respiratory tract. Because the nasal cavity is a common portal of entry, respiratory and olfactory epithelia are vulnerable targets for toxicological damage. The brain is a target for several environmental substances that may or may not be primarily airborne. Neurodevelopment and neuro-behaviour largely reflect brain development and its chemically induced modification, with resulting delays or deficits in development. It is generally believed that the developing brain is a particularly vulnerable target for chemical insult, and that such insult may have long lasting or even irreversible developmental consequences. Environmental exposures in uterus and during early life may permanently change the body’s structure, physiology and metabolism, and lead to diseases in adult life. Infants are particularly vulnerable because of their rapid growth and cell differentiation, immaturity of metabolic pathways and development of vital organ systems. The central nervous system has unprotected barriers and a broad time window of conformation, leading to a long period of vulnerability in the developmental process and to susceptibility to any environmental insult leading to neurological diseases.

References

64 Cites in Article
  1. I Beck-Speier,N Dayal,E Karg (2005). Oxidative stressand lipid mediators induced in alveola macrophagesby ultrafine particles.
  2. A Bellucci,A Westwood,E Ingram,F Casamenti,M Goedert,M Spillantini (2004). Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein.
  3. Patrick Breysse,Timothy Buckley,D’ann Williams,Christopher Beck,Seong-Joon Jo,Barry Merriman,Sukon Kanchanaraksa,Lee Swartz,Karen Callahan,Arlene Butz,Cynthia Rand,Gregory Diette,Jerry Krishnan,Adrian Moseley,Jean Curtin-Brosnan,Nowella Durkin,Peyton Eggleston (2005). Indoor exposures to air pollutants and allergens in the homes of asthmatic children in inner-city Baltimore.
  4. L Calder ´on-Garcidue˜nas,N Osnaya,A Rodr´õ Guez-Alcaraz,A Villarreal-Calder ´on (1997). DNA damage in nasal respiratory epithelium from children exposed to urban pollution.
  5. L Calder ´on-Garcidue˜nas,A Rodr´õ Guez-Alcaraz,A Villarreal-Calder ´on,O Lyght,D Janszen,K Morgan (1998). Nasal epithelium as a sentinel for airborne environmental pollution.
  6. L Calder´on-Garcidue˜nas,A Mora-Tiscare˜no,C Chung,G Valencia,L Fordham,R Garcia,N Osnaya,L Romero,H Acu˜na,A Villarreal-Calder ´on,R Devlin,Hs (2000). Exposure to air pollution is associated with lung hyper inhalation in healthy children and adolescents in Southwest Mexico City. A Pilot Study.
  7. Lilian Calderón-Garcidueñas,Gildardo Valencia-Salazar,Antonio Rodríguez-Alcaraz,Todd Gambling,Raquel García,Norma Osnaya,Anna Villarreal-Calderón,Robert Devlin,Johnny Carson (2001). Ultrastructural Nasal Pathology in Children Chronically and Sequentially Exposed to Air Pollutants.
  8. L Calder ´on-Garcidue˜nas,A Mora-Tiscare ˜no,L Fordham,C Chung,R Garcia,N Osnaya,J Hernandez,H Acu˜na,T Gambling,A Villarreal-Calder ´on,J Carson,H Koren,R &devlin (2001). Canines as sentinelspecies for assessing chronic exposures to airpollutants: Part1. Respiratory pathology.
  9. L Calder ´on-Garcidue˜nas,T Gambling,H Acu˜na,R Garcia,N Osnaya,S Monroy,A Villarreal-Calder ´on,J Carson,H Koren,R Devlin (2001). Canines as Sentinel Species for Assessing Chronic Exposures to Air Pollutants: Part 2. Cardiac Pathology.
  10. L Calderón-Garcidue~nas,R Devlin,F Miller (2001). Respiratory tract pathology and cytokine imbalance in clinically healthy children chronically and sequentially exposed to air pollutants.
  11. Caldero´n-Garciduen˜ As,L Azzarelli,B Acuna,H (2002). Air pollution and brain damage.
  12. Caldero´n-Garciduen˜ As,L Reed,W Maronpot,R (2004). Brain inflammation and 13.
  13. Arezoo Campbell (2004). Inflammation, Neurodegenerative Diseases, and Environmental Exposures.
  14. A Campbell,M Oldham,A Becaria,S Bondy,D Meacher,C Sioutas,C Misra,L Mendez,M Kleinman (2005). Particulate Matter in Polluted Air May Increase Biomarkers of Inflammation in Mouse Brain.
  15. C Clark,R Martin,E Van Kempen (2006). Exposure-effect relations between aircraftand road traffic noise exposure at school and reading comprehension: the RANCH project.
  16. Jan De Groot,Frank‐erik De Leeuw,Matthijs Oudkerk,Jan Van Gijn,Albert Hofman,Jellemer Jolles,Monique Breteler (2002). Periventricular cerebral white matter lesions predict rate of cognitive decline.
  17. A Elder,R Gelein,V Silva (2006). Translocation of inhale dultra fine manganese oxide particles to the central nervous system.
  18. Florian Gackière,Layal Saliba,Agnès Baude,Olivier Bosler,Caroline Strube (2011). Ozone inhalation activates stress‐responsive regions of the CNS.
  19. Sonia Gurgueira,Joy Lawrence,Brent Coull,G Murthy,Beatriz González-Flecha (2002). Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation..
  20. J Henriksson,H Tj¨alve (2000). Manganese Taken Up into the CNS via the Olfactory Pathway in Rats Affects Astrocytes.
  21. T Hirai,S Kojima,A Shimada,T Umemura,M Sakai,C Itakurat (1996). Age‐related changes in the olfactory system of dogs.
  22. Seishiro Hirano,Akiko Furuyama,Eiko Koike,Takahiro Kobayashi (2006). Oxidative-stress potency of organic extracts of diesel exhaust and urban fine particles in rat heart microvessel endothelial cells.
  23. Christoph Hock,Sidonie Golombowski,Franz Müller-Spahn,Oliver Peschel,Andreas Riederer,Alphonse Probst,Eva-Maria Mandelkow,Jürgen Unger (1998). Histological Markers in Nasal Mucosa of Patients with Alzheimer’s Disease.
  24. Howard Hoffman,Erick Ishii,Robert Macturk (1998). Age‐Related Changes in the Prevalence of Smell/Taste Problems among the United States Adult Population: Results of the 1994 Disability Supplement to the National Health Interview Survey (NHIS).
  25. Carolina Johansson,Anna Castoldi,Natalia Onishchenko,Luigi Manzo,Marie Vahter,Sandra Ceccatelli (2007). Neurobehavioural and molecular changes induced by methylmercury exposure during development.
  26. Frank Kelly (2004). Dietary antioxidants and environmental stress.
  27. J Kim (2004). Ambient Air Pollution: Health Hazards to Children.
  28. Kovács,Cairns,Lantos (1999). β‐Amyloid deposition and neurofibrillary tangle formation in the olfactory bulb in ageing and Alzheimer’s disease.
  29. H Kumar (2011). Air pollution and neurobehavioural functions in children: Evidence from Moradabad.
  30. H Kumar,A Sharma (2011). Black carbon exposure and its effect on cognitive functions of children in Greater Noida (India).
  31. B Lanphear,R Hornung,J Khoury (2005). Low-level environmental lead exposure and children's intellectualfunction: an international Chronic Ill Effects of Air Pollution in Children: Neurological Derailment © 2012 Global Journals Inc. (US) Alzheimer's-like pathology inindividuals exposed to severe air pollution.
  32. Seija Lehnardt,Leon Massillon,Pamela Follett,Frances Jensen,Rajiv Ratan,Paul Rosenberg,Joseph Volpe,Timothy Vartanian (2003). Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway.
  33. Shane Liddelow (2011). Fluids and barriers of the CNS: a historical viewpoint.
  34. D Lin,J Ngai (1999). Development of the vertebrate main olfactory system.
  35. W Logan (1952). Mortality in the London fog incident.
  36. Ryohei Miyata,Stephan Van Eeden (2011). The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter.
  37. Sheba Mohankumar,Arezoo Campbell,Michelle Block,Bellina Veronesi (2008). Particulate matter, oxidative stress and neurotoxicity.
  38. K Morgan,T Monticello (1990). Airflow, gas.
  39. (2012). deposition, and lesion distribution in the nasal passages.
  40. K Narayan,M Ali,J Koplan (2010). Global noncommunicable diseases where worlds meet.
  41. (2004). NRPB Advisory Group on Non-ionising Radiation. Power frequency electromagnetic fields and the risk of cancer.
  42. D Nebert,V Vasiliou (2004). Analysis of the glutathioneS-transferase (GST) gene family.
  43. G Oberdörster,Z Sharp,V Atudorei,A Elder,R Gelein,W Kreyling,C Cox (2004). Translocation of Inhaled Ultrafine Particles to the Brain.
  44. Akira Oka,Sachio Takashima (1997). Induction of cyclo-oxygenase 2 in brains of patients with Downʼs syndrome and dementia of Alzheimer type.
  45. S Pajovic´,Z Saicic´,M Spasic´,V Petrovic´ (2003). The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats.
  46. Victoria Pearson,Nancy Rothwell,Sylvie Toulmond (1999). Excitotoxic brain damage in the rat induces interleukin-1? protein in microglia and astrocytes: Correlation with the progression of cell death.
  47. Frederica Perera,Virginia Rauh,Robin Whyatt,Wei-Yann Tsai,Deliang Tang,Diurka Diaz,Lori Hoepner,Dana Barr,Yi-Hsuan Tu,David Camann,Patrick Kinney (2006). Effect of Prenatal Exposure to Airborne Polycyclic Aromatic Hydrocarbonson Neurodevelopment in the First 3 Years of Life among Inner-City Children.
  48. A Peters,B Veronesi,L Caldero´n-Garciduen˜as (2006). Translocation and potential neurological effects of fine and ultrafine particles: a critical update.
  49. Susan Porterfield (1994). Vulnerability of the Developing Brain to Thyroid Abnormalities: Environmental Insults to the Thyroid System.
  50. D Purves,G Augustine,D Fitzpatrick,W Hall,A Lamantia,O James,L Mcnamara,E White (2008). Unknown Title.
  51. I Romieu,F Castro-Giner,N Kunzli,J Sunyer (2008). Air pollution, oxidative stress and dietary supplementation: A review.
  52. N Rothwell,G Luheshi (2000). Interleukin 1 in the brain: biology, pathology and therapeutic target.
  53. R Ru¨ Ckerl,S Greven,P Ljungman (2007). Air pollution and inflammation (interleukin-6, C-reactive protein, fibrinogen) in myocardial infarction survivors.
  54. M Shima,M Adachi (2000). Effect of outdoor and indoor nitrogen dioxide on respiratory symptoms in school children.
  55. Cristina Sierra (2001). Cerebral white matter lesions in essential hypertension.
  56. D Silverthorn (2004). Night time aircraft noise exposure and children'scognitive performance.
  57. Michele Steiner,Markus Boller,Thorsten Schulz,Wouter Pronk (2007). Modelling heavy metal fluxes from traffic into the environment.
  58. W Streit,R Mrak,W Griffin (2004). Microglia and neuroinflammation: A pathological perspective.
  59. S Suglia,A Gryparis,R Wright,J Schwartz,R Wright (2008). Association of Black Carbon with Cognition among Children in a Prospective Birth Cohort Study.
  60. Tin-Tin-Win-Shwe,Shoji Yamamoto,Sohel Ahmed,Masaki Kakeyama,Takahiro Kobayashi,Hidekazu Fujimaki (2006). Brain cytokine and chemokine mRNA expression in mice induced by intranasal instillation with ultrafine carbon black.
  61. A Vandonkelaar,R Martin,M Brauer,R Kahn,R Levy,C Verduzco,P Villeneuve (2010). Global estimates of ambient fine particulate matter concentrations from satellite-based aerosol optical depth: development and application.
  62. Shunqin Wang,Jinliang Zhang,Xiaodong Zeng,Yimin Zeng,Shengchun Wang,Shuyun Chen (2009). Association of Traffic-Related Air Pollution with Children’s Neurobehavioral Functions in Quanzhou, China.
  63. Z Wszolek,K Markopoulou (1998). Olfactory dysfunction in Parkinson's disease.
  64. Kanato Yamagata,Katrin Andreasson,Walter Kaufmann,Carol Barnes,Paul Worley (1993). Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

yajvinder. 1970. \u201cChronic Ill Effects of Air Pollution in Children: Neurological Derailment\u201d. Global Journal of Human-Social Science - B: Geography, Environmental Science & Disaster Management GJHSS-B Volume 12 (GJHSS Volume 12 Issue B6): .

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GJHSS Volume 12 Issue B6
Pg. 63- 74
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Exposure to complex mixtures of air pollutants produces inflammation in the upper and lower respiratory tract. Because the nasal cavity is a common portal of entry, respiratory and olfactory epithelia are vulnerable targets for toxicological damage. The brain is a target for several environmental substances that may or may not be primarily airborne. Neurodevelopment and neuro-behaviour largely reflect brain development and its chemically induced modification, with resulting delays or deficits in development. It is generally believed that the developing brain is a particularly vulnerable target for chemical insult, and that such insult may have long lasting or even irreversible developmental consequences. Environmental exposures in uterus and during early life may permanently change the body’s structure, physiology and metabolism, and lead to diseases in adult life. Infants are particularly vulnerable because of their rapid growth and cell differentiation, immaturity of metabolic pathways and development of vital organ systems. The central nervous system has unprotected barriers and a broad time window of conformation, leading to a long period of vulnerability in the developmental process and to susceptibility to any environmental insult leading to neurological diseases.

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Chronic Ill Effects of Air Pollution in Children: Neurological Derailment

Dr. Harendra  Kumar
Dr. Harendra Kumar
Dr. Anita Sharma
Dr. Anita Sharma

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