Efficacy Of Halofantrine In Mice Infected With Plasmodium berghei

Efficacy Of Halofantrine In Mice Infected With Plasmodium berghei

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XF87N

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Efficacy Of Halofantrine In Mice Infected With Plasmodium berghei

Dr. Ologunde The Fedeeral Polytechnic Ado-Ekiti

C. A.

Olaoye

A. B.

Olofinjana

Akogun

O. O.

DOI

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Abstract

Drug adulteration is commonly reported in Nigeria. Halofantrine purchased in four different locations in Ondo and Ekiti state, Nigeria were tested in mice for their comparative efficacy. The average parasite clearance time (PCT) were 4.4±0.49, 4.2±0.40, 4.4±0.80 and 4.2±0.75 for Halofantrine coded HAL-AK, HAL-IO, HAL-AD and HAL-IK respectively. Also, average parasite clearance rate (PCR) were 8653±2557, 6895±1010, 5426±1850 and 6226±1850 respectively. The result shows that there was no significant difference in the PCR (P>0.05) between the drugs. All the halofantrine drugscompletely cleared the parasites within 4-5 days. The results of this study indicates that adulteration of Halofantrine is not presently in circulation in areas of Ondo and Ekiti states, South Western Nigeria

Efficacy Of Halofantrine In Mice Infected With Plasmodium berghei

Authors

Dr. Ologunde The Fedeeral Polytechnic Ado-Ekiti

C. A.

Olaoye

A. B.

Olofinjana

Akogun

O. O.

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How to Cite

Dr. Ologunde. 2012. “. Global Journal of Medical Research – F: Diseases GJMR-F Volume 12 (GJMR Volume 12 Issue F3): .

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

GJMR Volume 12 Issue F3
Pg. 1- 6

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Submission Received December 6, 2011
Accepted January 4, 2012
Published January 15, 2012

Keywords

Adulteration clearance rate halofantrine parasite clearance

Article Matrices

Total Score: 113

Country: Nigeria

Subject: Global Journal of Medical Research - F: Diseases

Authors: Dr. Ologunde, C. A., Olaoye, A. B., Olofinjana, O., Akogun, O. O. (PhD/Dr. count: 1)

View Count (all-time): 96

Total Views (Real + Logic): 5391

Total Downloads (simulated): 2625

Publish Date: 2012 05, Mon

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Total Views: 5391

Total Downloads: 2625

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