Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents

Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents

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A3EVA

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Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents

Dr. Nizam Baloch

Yasser M.S.A.Alkahraman

Mudassir A.Zaidi

Hassan M.F.Madkour University of Balochistan, Quetta, Pakistan and Ain Shams University, Cairo, Egypt.

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Abstract

The present work aims at study of antileishmanial activity of some 6, 8-dichloro-2-methyl-4H-chromen-4-one derivatives. The synthesized chromenes have been screened for antileishmanial activity on L. major parasite. The results were promising and showed that all compounds under investigation have some degree of activity against leishmania L. major parasite and compound 5 showed potential activity with IC50 value 0.58± 0.09 μg/ml, comparatively with the standard drug Amphotericin B.

Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents

Authors

Dr. Nizam Baloch

Yasser M.S.A.Alkahraman

Mudassir A.Zaidi

Hassan M.F.Madkour University of Balochistan, Quetta, Pakistan and Ain Shams University, Cairo, Egypt.

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How to Cite

Hassan M.F.Madkour. 2012. “. Global Journal of Science Frontier Research – B: Chemistry GJSFR-B Volume 12 (GJSFR Volume 12 Issue B7): .

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

GJSFR Volume 12 Issue B7
Pg. 27- 32

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Submission Received October 9, 2012
Accepted October 29, 2012
Published November 13, 2012

Keywords

2-methyl-4h-chromen-4-one carbon electrophiles and nucleophiles leishmaniasis

Article Matrices

Total Score: 109

Country: Egypt

Subject: Global Journal of Science Frontier Research - B: Chemistry

Authors: Dr. Nizam Baloch, Yasser M.S.A.Alkahraman, Mudassir A.Zaidi, Hassan M.F.Madkour (PhD/Dr. count: 1)

View Count (all-time): 92

Total Views (Real + Logic): 5198

Total Downloads (simulated): 2838

Publish Date: 2012 12, Sat

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Total Views: 5198

Total Downloads: 2838

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