Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents

Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents

Hassan M.F.Madkour

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Dr. Nizam Baloch

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Yasser M.S.A.Alkahraman

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Mudassir A.Zaidi

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University of Balochistan

Evaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents

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Abstract

The present work aims at study of antileishmanial activity of some 6, 8-dichloro-2methyl-4H-chromen-4-one derivatives. The synthesized chromenes have been screened for antileishmanial activity on L. major parasite. The results were promising and showed that all compounds under investigation have some degree of activity against leishmania L. major parasite and compound 5 showed potential activity with IC 50 value 0.58± 0.09 μg/ml, comparatively with the standard drug Amphotericin B.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Hassan M.F.Madkour. 2012. \u201cEvaluation of 6, 8-Dichloro-2-Methyl-4H-Chromen-4-One Derivatives as Antileishmanial Agents\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 12 (GJSFR Volume 12 Issue B7).

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GJSFR Volume 12 Issue B7

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords

2-methyl-4h-chromen-4-one carbon electrophiles and nucleophiles leishmaniasis

Submission ReceivedOctober 9, 2012
Peer Review Double Blind
Handling Editor
Accepted October 29, 2012
Published November 13, 2012

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v1.2

Issue date

December 8, 2012

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Article Matrices

Total Score: 109

Country: Egypt

Subject: Global Journal of Science Frontier Research - B: Chemistry

Authors: Dr. Nizam Baloch, Yasser M.S.A.Alkahraman, Mudassir A.Zaidi, Hassan M.F.Madkour (PhD/Dr. count: 1)

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Publish Date: 2012 12, Sat

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Total Views: 5349

Total Downloads: 2650

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