Design and Evaluation of Nanoparticulate Drug Delivery Systems for Imaging and Treatment of Malignant Brain Tumor

Design and Evaluation of Nanoparticulate Drug Delivery Systems for Imaging and Treatment of Malignant Brain Tumor

Minyahil A. Woldu MSc in Clinical pharmacy

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Jimma Likisa Lenjissa

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Gizaw Dabessa Satessa

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α Ambo University

Design and Evaluation of Nanoparticulate Drug Delivery Systems for Imaging and Treatment of Malignant Brain Tumor

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Abstract

Malignant brain tumours are one of the most devastating human cancers associated with high mortality and morbidity rates. The median survival of malignant glioma patie-nts ranges between 3 and 16 months and has virtually rema-ined unchanged during the last 3 decades. Difficulties in early detection, local recurrence, and resistance to conventional therapies are the major reasons for failure in malignant brain tumour treatment. The therapy of malignant gliomas is further limited by the inadequate delivery of therapeutic agents to the brain due to the presence of the blood-brain barrier, blood-brain-tumor barrier as well as non-specificity targeting. Nanoparticles (NPs) have drawn increased interest in treating malignant brain tumours due to their potential to act as a vector for brain delivery and to provide tumourspecific detection and treatment. If designed appropriately, NPs may act as a drug vehicle able to target tumor tissues or cells, and protect the drug from inactivation during its transport. The aim of this article was to provide brief overview of nanoparticulate drug delivery systems for imaging and treatment of brain cancer and to evaluate their safety in clinical use. Besides invasive physical methods to bypass or disrupt the BBB and/or BBTB, other methods like pharmacological and physio-logic approach are possible.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Minyahil A. Woldu. 2014. \u201cDesign and Evaluation of Nanoparticulate Drug Delivery Systems for Imaging and Treatment of Malignant Brain Tumor\u201d. Global Journal of Science Frontier Research - G: Bio-Tech & Genetics GJSFR-G Volume 14 (GJSFR Volume 14 Issue G1): .

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GJSFR Volume 14 Issue G1
Pg. 15- 25

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords

nanomedicine nanoparticle nanoparticulate nanoparticulate drug delivery system nanovectors

Submission ReceivedDecember 23, 2013
Peer Review Double Blind
Handling Editor
Accepted January 16, 2014
Published January 28, 2014

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v1.2

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May 7, 2014

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Total Score: 103

Country: Unknown

Subject: Global Journal of Science Frontier Research - G: Bio-Tech & Genetics

Authors: Minyahil A. Woldu, Jimma Likisa Lenjissa, Gizaw Dabessa Satessa (PhD/Dr. count: 0)

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