Urinary Excretion and Renal Clearance of Nimesulide in Male Volunteers

Urinary Excretion and Renal Clearance of Nimesulide in Male Volunteers

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PDDTM7BA8H

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Urinary Excretion and Renal Clearance of Nimesulide in Male Volunteers

Bilal Ahmed Department of Chemistry and Biochemistry University of Agriculture Faisalabad

Tahira Iqbal

Huma Mahboob

Farah Latif

Imtiaz Sohail.

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Abstract

Drugs are eliminated from the body either unchanged as the parent drug or as metabolites. Nimesulide drug belongs to a wide class of medicines called antiinflammatory nonsteroidal drugs (NSAID). NSAIDs are well known for their antipyretic, anti-inflammatory, and analgesic properties. Renal clearance of nimesulide correlated with creatinine clearance. The present research work was planed to determine urinary excretion and renal clearance of nimesulide after its oral administration. Blood and urine samples of the human male volunteers (n=10), after the oral administration of drug, were collected at predetermined time intervals. The concentration of the nimesulide in urine and plasma of male volunteers was determined by HPLC. Statistical analysis was performed in order to determine the significance of the results.

Urinary Excretion and Renal Clearance of Nimesulide in Male Volunteers

Authors

Bilal Ahmed Department of Chemistry and Biochemistry University of Agriculture Faisalabad

Tahira Iqbal

Huma Mahboob

Farah Latif

Imtiaz Sohail.

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How to Cite

Bilal Ahmed. 2014. “. Global Journal of Medical Research – B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B1): .

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

GJMR Volume 14 Issue B1
Pg. 23- 27

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Submission Received December 6, 2013
Accepted January 4, 2014
Published January 15, 2014

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Article Matrices

Total Score: 105

Country: Unknown

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Bilal Ahmed, Tahira Iqbal, Huma Mahboob, Farah Latif, Imtiaz Sohail. (PhD/Dr. count: 0)

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Publish Date: 2014 03, Thu

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Total Views: 4679

Total Downloads: 2432

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