Synthese, Characterization and Antibacterial Activity of Macrocyclic Schiff Bases

Synthese, Characterization and Antibacterial Activity of Macrocyclic Schiff Bases

Hamid Hussein Eissa

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Hajjah University

Synthese, Characterization and Antibacterial Activity of Macrocyclic Schiff Bases

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Abstract

In this work we focused on the synthesis of two new macrocyclic Schiff bases: (III), ( IV), (VI) containing nitrogen -oxygen donor atoms were synthesized by condensation of intermediate compounds: 1,6-bis (2-formylphenel) hexane (I)and α,α’-bis (2-carboxyaldehyde phenoxy) xylene(II) with 4,4′-Diamino-diphenylmethane and 4-Aminophenyl sulfone. Also new open Schiff bases (V) which were prepared by condensation of benzylhydrazidewith 1, 6-bis (2-formylphenel) hexane (I). Identification of these macrocyclic Schiff bases: 1,16-di aza-3,4,13,14-tri phenyl-17,25 -di phenyl methane-5,12-di oxacyclo penta-icozane-1,15-diene(III), 1,16-di aza-3,4, 7, 10, 13,14-tri phenyl-17,25 -di phenyl methan-5,8-di oxacyclo penta-icozane-1,15-diene. (IV).1,16-di aza-3,4,13,14-tri phenyl-17,25 -di phenyl sulphide-5,12-di oxacyclo penta-icozane-1,15-diene(V), And N’,N’-(2,2′-(hexane-1,6-bis(oxy))bis(2,1-phenylene)) bis(methanylidene) dibenzhydra-zide. (VI).The Schiff bases were checked by different spectral technique (LC-MS, 1H-NMR, IR, elemental analyses). The new Schiff Bases were studied for antibacterial activities against (Bacillus subtilis and Staphylococcus aureus) are Gram positive and (Salmonella typhi and Escherichia coli) are Gram negative. The ligands were exhibited a variable activity of inhibition on the growth of the bacteria.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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How to Cite This Article

Hamid Hussein Eissa. 2014. \u201cSynthese, Characterization and Antibacterial Activity of Macrocyclic Schiff Bases\u201d. Global Journal of Science Frontier Research - B: Chemistry GJSFR-B Volume 14 (GJSFR Volume 14 Issue B2).

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GJSFR Volume 14 Issue B2

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords

antibacterial activity macrocyclic schiff bases open schiff bases spectral technique

Submission ReceivedMay 4, 2014
Peer Review Double Blind
Handling Editor
Accepted May 27, 2014
Published June 8, 2014

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v1.2

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May 28, 2014

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Total Score: 101

Country: Yemen

Subject: Global Journal of Science Frontier Research - B: Chemistry

Authors: Hamid Hussein Eissa (PhD/Dr. count: 0)

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