Oxidative Stress Induced Carbonyl Group Incorporation to Human RBC Membrane: Role in Vivo Senescence of Erythrocyte.

Oxidative Stress Induced Carbonyl Group Incorporation to Human RBC Membrane: Role in Vivo Senescence of Erythrocyte.

Arghya Sur

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Hemontika Chakraborty

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Arindam Basu

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Sasanka Chakrabarti

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Oxidative Stress Induced Carbonyl Group Incorporation to Human RBC Membrane: Role in vivo Senescence of Erythrocyte.

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Abstract

This study was focused to identify the link between oxidative stress and senescence of erythrocytes in vivo. To elucidate this mechanism, various modification of RBC membrane proteins and lipids were analyzed invitro, exposing them to oxidative stress and the results were compared with the changes observed in erythrocytes undergoing senescence in vivo. The other objective was to confirm the mechanism of autoantibody mediated removal of aged RBCs. Our results established that increased lipid peroxidation products, followed by the enhanced damage of RBC membrane protein caused increased RBC membrane protein carbonylation, to normal red cells exposed to the in vitro Fe 2+ & ascorbate induced oxidative stress. It was presumable that these changes were mediated by hydroxyl (ȮH) radicals. Further, similar changes were also seen in percoll gradient age fractionated high density aged RBCs.

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How to Cite This Article

Arghya Sur. 2014. \u201cOxidative Stress Induced Carbonyl Group Incorporation to Human RBC Membrane: Role in Vivo Senescence of Erythrocyte.\u201d. Global Journal of Medical Research - C: Microbiology & Pathology GJMR-C Volume 14 (GJMR Volume 14 Issue C7).

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GJMR Volume 14 Issue C7

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

autoantibody to RBC human RBC membrane oxidative membrane damage oxygen free radical protein carbonylation ROS senescence of RBC

Submission ReceivedDecember 15, 2013
Peer Review Double Blind
Handling Editor
Accepted December 31, 2013
Published January 15, 2014

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December 24, 2014

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Total Score: 104

Country: India

Subject: Global Journal of Medical Research - C: Microbiology & Pathology

Authors: Arghya Sur, Hemontika Chakraborty, Arindam Basu, Sasanka Chakrabarti (PhD/Dr. count: 0)

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