Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

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PDDTM7I222

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Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

K.Hariprasath Adarsa College of Pharmacy

I. Sudheer babu

P.Venkatesh

U.Upendra Rao.

DOI

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Abstract

In our study we synthesized schiff’ base of sulphadiazine on treating with aromatic aldehydes like para diethyl amino benzyldehyde and paradimethyl amino benzyldehyde. The synthesized schiff’s bases were converted to its cationic amphiphilic bases by treating with methyl iodide. The cationic schiff bases were converted to metal complexes by treating with metals like copper chloride (CuCl2), zinc chloride (ZnCl2) and cadmium chloride (CdCl2). All the synthesized compounds were characterized by elemental analysis, IR and H1 NMR. Synthesized compounds were screened for anti-inflammatory and antidepressant activity. Copper metal complexes showed excellent anti-inflammatory activity and zinc metal complexes showed excellent antidepressant activity.

Antidepressant and Anti-Inflammatory Activities of Cationic Amphiphilic Complexes of Sulphadiazine

Authors

K.Hariprasath Adarsa College of Pharmacy

I. Sudheer babu

P.Venkatesh

U.Upendra Rao.

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How to Cite

K.Hariprasath. 2015. “. Global Journal of Medical Research – B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 14 (GJMR Volume 14 Issue B7): .

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

GJMR Volume 14 Issue B7
Pg. 9- 16

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Submission Received December 11, 2013
Accepted January 4, 2014
Published January 15, 2014

Keywords

anti-inflammatory and antidepressant activity cationic amphiphilic bases metal complexes Schiff base

Article Matrices

Total Score: 104

Country: India

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: K.Hariprasath, I. Sudheer babu, P.Venkatesh, U.Upendra Rao. (PhD/Dr. count: 0)

View Count (all-time): 155

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Publish Date: 2015 01, Mon

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Total Views: 4391

Total Downloads: 2088

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