In Vivo Anti-Inflammatory and in Vitro Antioxidant Activities of Toona Ciliata Leaves Native to Bangladesh
The study was performed to assess the antiinflammatory, antioxidant activities and identify the polyphenols of Toona ciliata grown in Bangladesh. Antiinflammatory activity was examined by the methods of carrageenan and histamine-induced paw edema. At the dose of 400 mg/kg, effective anti-inflammatory activity (P<0.01) was observed in rats for both the test models of carrageenan and histamine-induced paw edema, compared to indomethacin. In ABTS scavenging assay, IC50 value was found significant (5.50μg/ml) compared to ascorbic acid (12.01μg/ml). The maximum absorbance of reducing power was obtained 0.4939 at 250μg/ml relative to ascorbic acid (1.1115μg/ml). Total antioxidant capacity, total phenolic and flavonoid content were found to be 357.1 mg/g ascorbic acid, 239.2 mg/g gallic acid, and 98.36 mg/g quercetin equivalent, respectively. During HPLC analysis, catechin and ellagic acid were determined in considerable amounts (825.95 and 416.70 mg/100g extract, respectively). The findings suggest that Toona ciliata could be a potential source of natural antioxidant.
