The Scientific Discussion of Revealing Key Issue Aspects of Features of Simulation of Inflammatory Pain through AMPA Receptor Subunits of Exosome Origin
The aim of the research was to study key issue aspects of features of simulation of inflammatory pain through AMPA receptor subunits of exosome origin in mice. The mechanism of functional modulation of AMPARs by their auxiliary subunits will benefit from further efforts to reach a tipping point where it will be useful for the development of improved therapies. Lipids require special attention because they may play an important role in the function of the AMPAR accessory subunit. Structural studies should only provide snapshots of complexes in action. Therefore, functional studies and molecular dynamics simulation approaches are expected to play an equally important role. Native AMPAR complexes contain more than one type of accessory subunits.
