The Herbal Drug, Polysaccharide K, has an Immunological and Synergistic Anticancer Effect with Cetuximab for Gastrointestinal Cancer in Vivo

The Herbal Drug, Polysaccharide K, has an Immunological and Synergistic Anticancer Effect with Cetuximab for Gastrointestinal Cancer in Vivo

hara masa

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Masayasu Hara

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Takaya Nagasaki

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Hiromitsu Takeyama

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Nagoya City University

The Herbal Drug, Polysaccharide K, has an Immunological and Synergistic Anticancer Effect with Cetuximab for Gastrointestinal Cancer in Vivo

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Abstract

Cetuximab, an anti-epidermal growth factor receptor (EGFR) antibody, has been widely used for therapy of several kinds of malignant diseases. However, the anticancer effect is incomplete. The purpose of this study was to examine the synergism between the herbal drug, Polysaccharide K, and Cetuximab against gastrointestinal cancer cell lines in vitro and in vivo. Two gastrointestinal cancer cell lines positive for EGFR expression were used for this study. In the in vivo study, mice were xenografted with cancer cell lines subcutaneously. Neither PSK nor Cetuximab suppressed cell proliferation. However, when both drugs were administered, cancer growth was suppressed significantly compared with treatment with Cetuximab alone. This study demonstrated that PSK has the potential to enhance Cetuximab’s effect on gastrointestinal cancer.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

hara masa. 2013. \u201cThe Herbal Drug, Polysaccharide K, has an Immunological and Synergistic Anticancer Effect with Cetuximab for Gastrointestinal Cancer in Vivo\u201d. Unknown Journal GJMR-I Volume 13 (GJMR Volume 13 Issue I3).

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Submission ReceivedApril 5, 2013
Peer Review Double Blind
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Accepted May 4, 2013
Published May 15, 2013

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v1.2

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October 31, 2013

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Article Matrices

Total Score: 148

Country: Japan

Subject: Uncategorized

Authors: Masayasu Hara, Takaya Nagasaki, Hiromitsu Takeyama (PhD/Dr. count: 0)

View Count (all-time): 138

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Total Downloads (simulated): 2331

Publish Date: 2013 10, Thu

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Total Views: 4781

Total Downloads: 2331

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