Comparative Analysis of Adverse Drug Reactions in Directly Observed Treatment Short Course (DOTS) in TB Patients

Comparative Analysis of Adverse Drug Reactions in Directly Observed Treatment Short Course (DOTS) in TB Patients

Md. Motiur Rahman

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Ahmedullah Mishuk

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Shimul Halder

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Abul Kalam Lutful Kabir

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University of Dhaka

Comparative Analysis of Adverse Drug Reactions in Directly Observed Treatment Short Course (DOTS) in TB Patients

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Abstract

This study describes the occurrences of adverse drug reactions (ADRs) caused by anti tubercular (TB) drugs employed in Directly Observed Treatment Short Course (DOTS) from ten years of ADR data (from 2002 to 2012) reported in various articles. The frequency of each type of ADR was analyzed and compared. A total of 10,219 patients were studied. Among them, 8,047 (78.75%) patients demonstrated positive responses to at least one type of ADR. Dermatological reactions predominated among the ADRs which occurred in 4389 (42.95%) patients followed by hepatotoxicity in 1634 (15.99%) cases. Female patients were more prone to ADRs as compared to the male patients. The occurrence of ADRs is mainly attributed to the combination therapy along with the prolonged medication period. A colossal amount of ADRs were observed during the study which must be monitored and managed properly throughout the DOTS therapy in order to prevent life-threatening harmful effects.

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12 Cites in Article

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Md. Motiur Rahman. 2014. \u201cComparative Analysis of Adverse Drug Reactions in Directly Observed Treatment Short Course (DOTS) in TB Patients\u201d. Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine GJMR-B Volume 13 (GJMR Volume 13 Issue B6).

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GJMR Volume 13 Issue B6

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Journal Specifications

Crossref Journal DOI 10.17406/gjmra

Print ISSN 0975-5888

e-ISSN 2249-4618

Keywords

adverse drug reactions dots tuberculosis

Submission ReceivedDecember 11, 2012
Peer Review Double Blind
Handling Editor
Accepted January 5, 2013
Published January 15, 2013

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v1.2

Issue date

January 3, 2014

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Article Matrices

Total Score: 104

Country: Bangladesh

Subject: Global Journal of Medical Research - B: Pharma, Drug Discovery, Toxicology & Medicine

Authors: Md. Motiur Rahman, Ahmedullah Mishuk, Shimul Halder, Abul Kalam Lutful Kabir (PhD/Dr. count: 0)

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Total Views: 4760

Total Downloads: 2476

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