Serum Homocysteine and Paraoxonase1 Levels in Women with Polycystic Ovary Syndrome Treated with Metformin Versus Metformin and Folic Acid

1
Dr. Tarek H. Abed Tawfik Al-Khyat
Dr. Tarek H. Abed Tawfik Al-Khyat
2
Dr. Melal Mohammed Al-Jeborry
Dr. Melal Mohammed Al-Jeborry
3
Qusay Mohsin Kadium
Qusay Mohsin Kadium
3 University of Babylon

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Serum Homocysteine and Paraoxonase1 Levels in Women with Polycystic Ovary Syndrome Treated with Metformin Versus Metformin and Folic Acid Banner

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The objective of our study was to evaluate, in a population of Togolese People Living With HIV(PLWHIV), the agreement between three scores derived from the general population namely the Framingham score, the Systematic Coronary Risk Evaluation (SCORE), the evaluation of the cardiovascular risk (CVR) according to the World Health Organization.
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28 Cites in Articles

References

  1. L Nardo,S Patchava,I Laing (2008). Polycystic ovary syndrome: Pathophysiology, molecular aspects and clinical implications.
  2. J Oates,S Abraham (2010). LIEWELLYN-JONES Fundamentals of obstetrics and gynaecology 9 th edition.
  3. B Presannakumari,Sareena Gilvaz (2011). Polycystic Ovarian Syndrome.
  4. E Keith (2011). Dewhurst ' s Textbook of Obstetrics and Gynaecology.
  5. C De La,R Usandizga,M Sancha,F Magdaleon,A Herranz,E Carillo (2003). Homocysteine, Folic acid and B-group vitamins in obstetrics and gynecology.
  6. Kirsten Holven,Pål Aukrust,Kjetil Retterstøl,Kari Otterdal,Vigdis Bjerkeli,Leiv Ose,Marit Nenseter,Bente Halvorsen (2008). The Antiatherogenic Function of HDL Is Impaired in Hyperhomocysteinemic Subjects.
  7. D Draganov,J Teiber,A Speelman,Y Osawa,R Sunahara,La Du,B (2005). Human paraoxonases (PON1, PON2 and PON3) are lactonases with overlapping and distinct substrate specificities.
  8. Joseph Loscalzo (2008). Paraoxonase and Coronary Heart Disease Risk.
  9. J Zhang,P Fan,H Liu,H Bai1,Wang,F Zhang (2012). Apolipoprotein A-I and B levels, dyslipidemia and metabolic syndrome in south-west Chinese women with PCOS.
  10. Y Lee,S Choi,K Lee,D Kim (2011). Apolipoprotein B/A1 ratio is associated with free androgen index and visceral adiposity and may be an indicator of metabolic syndrome in male children and adolescents.
  11. T Hiroyuki,K Shintaro,S Matsushima (2011). Oxidative stress and heart failure.
  12. R Webster,V Roberts,L Myatt (2008). Protein nitration in placenta -functional signifycance.
  13. Kaïs Al-Gubory,Paul Fowler,Catherine Garrel (2010). The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes.
  14. Dean Eurich,Finlay Mcalister,David Blackburn,Sumit Majumdar,Ross Tsuyuki,Janice Varney,Jeffrey Johnson (2007). Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review.
  15. H Lashen (2010). Role of Metformin in the management of polycystic ovary syndrome.
  16. L Xu,Z Huang,X Xiaoying He,X Wan,D Fang,Y Li (2013). Adverse effect of Metformin therapy on serum vitamin B12 andfolate: Short-term treatment causes disadvantages.
  17. Signe Altmäe,Anneli Stavreus-Evers,Jonatan Ruiz,Margit Laanpere,Tiina Syvänen,Agneta Yngve,Andres Salumets,Torbjörn Nilsson (2010). Variations in folate pathway genes are associated with unexplained female infertility.
  18. Y Goh,G Koren (2008). Folic acid in pregnancy and fetal outcomes.
  19. M Schatchter,A Raziel,S Friedler,D Strassburger,O Orna Bern,R Ron-El (2003). Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine.
  20. Esra Kilicdag,Tayfun Bagis,Ebru Tarim,Erdogan Aslan,Serkan Erkanli,Erhan Simsek,Bulent Haydardedeoglu,Esra Kuscu (2005). Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial.
  21. Stefano Palomba,Angela Falbo,Francesco Giallauria,Tiziana Russo,Achille Tolino,Fulvio Zullo,Annamaria Colao,Francesco Orio (2010). Effects of Metformin With or Without Supplementation With Folate on Homocysteine Levels and Vascular Endothelium of Women With Polycystic Ovary Syndrome.
  22. E Kilicdag,T Bagis,E Tarim,E Aslan,S Erkanli,E Simsek,B Haydardedeoglu,E Kuscu (2005). Homocysteine levels in polycystic ovarian syndrome treated with Metformin versus rosiglitazone.
  23. Murat Yilmaz,Neslihan Bukan,Göksun Ayvaz,Ayhan Karakoç,Füsun Törüner,Nuri Çakir,Metin Arslan (2005). The effects of rosiglitazone and metformin on oxidative stress and homocysteine levels in lean patients with polycystic ovary syndrome.
  24. Necat Yilmaz (2012). State of the art paper Relationship between paraoxonase and homocysteine: crossroads of oxidative diseases.
  25. Clifford Bailey (2008). Metformin: Effects on Micro and Macrovascular Complications in Type 2 Diabetes.
  26. E Nakano,J Higgins,H Powers (2001). Folate protects against oxidative modification of human LDL.
  27. E Elia,V Sander,C Luchetti,M Solano,G Girolamo,Di,C Gonzalez,A Motta1 (2006). The mechanisms involved in the action of Metformin in regulating ovarian function in hyperandrogenized mice.
  28. J Racek,Rusnakova,L Trefil,K Siala (2005). The influence of folate and antioxidants on homocysteine levels and oxidative stress in patients with hyperlipidemia and hyperhomocysteinemia.

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

Qusay Mohsin Kadium. 2013. \u201cSerum Homocysteine and Paraoxonase1 Levels in Women with Polycystic Ovary Syndrome Treated with Metformin Versus Metformin and Folic Acid\u201d. Global Journal of Science Frontier Research - G: Bio-Tech & Genetics GJSFR-G Volume 13 (GJSFR Volume 13 Issue G2): .

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GJSFR Volume 13 Issue G2
Pg. 35- 40
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Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

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v1.2

Issue date

October 30, 2013

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English

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Serum Homocysteine and Paraoxonase1 Levels in Women with Polycystic Ovary Syndrome Treated with Metformin Versus Metformin and Folic Acid

Dr. Tarek H. Abed Tawfik Al-Khyat
Dr. Tarek H. Abed Tawfik Al-Khyat
Dr. Melal Mohammed Al-Jeborry
Dr. Melal Mohammed Al-Jeborry
Qusay Mohsin Kadium
Qusay Mohsin Kadium University of Babylon

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