Role of Hepatitis B Virus Surface Antigen Quantification in e Antigen Negative Chronic Hepatitis B Infection

Role of Hepatitis B Virus Surface Antigen Quantification in e Antigen Negative Chronic Hepatitis B Infection

R.M.Mukherjee

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Jyothi Arava

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P.Balkumar Reddy

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P.N.Rao

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R.Gupta

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D.N.Reddy

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Asian Health Care Foundation

Role of Hepatitis B Virus Surface Antigen Quantification in e Antigen Negative Chronic Hepatitis B Infection

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Abstract

Background/Aim: Hepatitis B surface antigen(HBsAg) is routinely detected qualitatively in Hepatitis B Virus(HBV) infection where its persistence beyond 6 months defines chronic hepatitis B(CHB) infection. Hepatitis B e antigen (HBeAg) usually indicates active HBV replication and risk of transmission of infection. In spite of the emerging use of chemiluminescence based quantitative HBsAg assays for therapeutic monitoring of the patients, we measured HBsAg concentration by sandwich ELISA as a cost effective alternative to ascertain the role of HBsAg levels as surrogate marker of untreated HBeAg negative subjects having CHB infection.

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Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

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How to Cite This Article

R.M.Mukherjee. 2014. \u201cRole of Hepatitis B Virus Surface Antigen Quantification in e Antigen Negative Chronic Hepatitis B Infection\u201d. Global Journal of Science Frontier Research - G: Bio-Tech & Genetics GJSFR-G Volume 13 (GJSFR Volume 13 Issue G3).

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GJSFR Volume 13 Issue G3

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Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords

CHB infection elisa HBeAg negative HBsAg quantification viral load

Submission ReceivedOctober 21, 2013
Peer Review Double Blind
Handling Editor
Accepted November 15, 2013
Published November 29, 2013

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v1.2

Issue date

January 23, 2014

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Article Matrices

Total Score: 106

Country: India

Subject: Global Journal of Science Frontier Research - G: Bio-Tech & Genetics

Authors: R.M.Mukherjee, Jyothi Arava, P.Balkumar Reddy, P.N.Rao, R.Gupta, D.N.Reddy (PhD/Dr. count: 0)

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