Ajibade, V.A
Phytochemistry and Bioactivity Studies Diverse Scientific Research Studies Ethnobotanical and Medicinal Plants Studies Salmonella and Campylobacter epidemiology Phytochemistry and Biological Activities Nigella sativa pharmacological applications Hibiscus Plant Research Studies Pharmacology and Nanomedicine Research Health, Toxicology and Mutagenesis Pharmacology General Health Professions Plant Science Food Science Complementary and alternative medicine Drug Discovery

Experience

The Federal Polytechnic, Ado-Ekiti

2011 - 2019

Editors Role

Reviewer

GJSFR

2016 - Present

Research

Antibacterial Effects of Phyllanthusdiscoideus and Terminaliaavicennioides on Methicillin Resistant Staphylococcusaureus Isolated from Primary School Pupils in Ekiti-State

Article August 24, 2016

The Antibacterial effects of Phyllanthus discoideus and Terminalia avicennioides on Methicillin resistant Staphylococcus aureus were studied. Three hundred and twenty four (324) samples were collected from the skin, boil and wound of pupils in twelve (12) selected primary schools in Ekiti State, they were inoculated by streaking on to dried mannitol salt agar plates. Staph aureus was identified by agar diffusion method using methicillin disc. Susceptibility testing of the methicillin resistant Staphylococcus aureus to the crude extracts of the leaves of Phyllanthus discoideus and Terminalia avicennioides, was carried out at various concentrations((10 to100mg/ml).Out of the 324 isolates, 151 (47%) were methicillin resistant and 118 (78%)) were susceptible to P. discoideusextract in 151 MRSA isolates, while the remaining 33MRSA isolates were resistant. 121 MRSA isolates were susceptible to T. avicennioides extract, 30 were resistant to the extract, the percentage susceptible was 80%. The susceptibility of MRSA isolates to the leave extracts of the two plants was very high,it shows that the crude extracts from the leave of these plants could be used as therapies for the treatment of diseases that are associated with methicillin resistant staphylococcus aureus.

Histopathological and Toxicological effects of crude saponin extract from Phyllanthus niruri, L (Syn. P. franternus. Webster) on Organs in animal studies

Article January 1, 1970

The histopathological view of liver, intestines and kidney of bacterial infected rabbits, fed with 100mg/ml saponin extracted from Phyllanthus niruri over a period of seven days was carried out to determine the effect of the plant extract on these organs after treatment. Saponin was administered as strawberry suspension at a dose of 10mg per day (divided into four doses) to ten rabbits, nine of which were fed with food contaminated with 0.5mL bacterial suspension obtained by McFarland standardization (10% Barium sulfate) after starvation for 6hrs . Multiple foci of tubular necrosis and haemorrhages in the kidney, marked hyperplasia of the mucosal layer of the small intestine, and a mild periportal lymphocytic cellular infiltration of the liver of the treated rabbits were observed. Plasma urea, uric acid, creatinine and blood glucose levels increased significantly (p < 0.05) in the treated rabbits. Plasma protein, hemoglobin, red blood cell and leukocyte counts were not altered adversely. No significant changes were observed in the enzymes’ activity in all the groups of rabbits tested. The extract seems to show therapeutic actions on infections caused by E. coli and Salmonella typhi without any adverse effect on the organs.