Bio
Dr. R. T. Kashinath is a Professor and Head of the Department of Biochemistry at Subbaiah Institute of Medical Sciences & Research Center, affiliated with Rajiv Gandhi University of Health Sciences, in Shimoga, Karnataka, India. He holds an MSc in Biochemistry and a PhD in Biochemistry (Medical Faculty) and is a Fellow of the International College of Surgeons (FICS). His research areas include membrane phospholipid/cholesterol ratio, thiol-disulfide balance, and endocrinology, diabetes and metabolism. He has published over 13 research papers in the Global Journal of Medical Research and served as a reviewer for the same journal. His previous institutional affiliations include Basaveshwara Medical College & Hospital (affiliated with Rajiv Gandhi University of Health Sciences), BLDE University (Sri B.M.Patil Medical College), and Vijayanagara Institute of Medical Sciences.
Educational Journey
MSc • Biochemistry
PhD • Biochemistry (Medical Faculty)
Experience
Subbaiah Institute of Medical Sciences & Research Center
Professor & Head of Department
2012 - 0 • BiochemistryVijayanagara Institute of Medical Sciences
0 - 0 • BiochemistryBasaveshwara Medical College & Hospital
0 - 0 • BiochemistryEditors Role
Reviewer
Global Journal of Medical Research
2012 -Affiliations
International College of Surgeons
Fellow
Member since 0Research
Protective Effects of Diallyl Disulfide Against Experimentally Induced Hepatoma in Mice
Many herbal extracts have been reported to modify significantly, the transformation of normal cells into neoplastic cells. Garlic and its extracts are known for their hypolipidemic, hypoglycemic, antiplatelet aggregating effect as well as for its anticancer effects. Many of these health beneficial effects of garlic are attributed to its principle organosulfur compound diallyl disulfide(DADS). It was thought that DADS may be involved in anticarcinogenic & antitumorogenic effect of garlic, hence the present work was undertaken to assess the protective effects of DADS in ehrlich ascites carcinoma (EAC) cells induced hepatoma in mice. The study has three groupsnormal group (group1), the EAC cells implanted mice (group 2) & DADS-treated EAC cells implanted mice (group 3). The results indicate a significant decrease in ascitic fluid volume, ascitic fluid cell count, liver tissue amino acid nitrogen levels, liver tissue glutaminase activity & liver tissue lactate levels as well as a increase in life span observed in group 3 mice as compared to group 2 mice, suggesting that DADS gives a significant protection in group3 mice probably by decreasing the anaerobic glucose utilization as well as by interfering with protein & deoxy ribonucleotide synthesis.
