Research
Breast Conserving Surgery and Whole Breast Radiation Therapy Followed by High Dose Rate Brachytherapy Boost Versus Electron Beam Boost in the Treatment of Early Breast Cancer in Young Indian Women: Which is Cosmetically Better?
Breast conserving treatment (BCT) is the treatment of choice in early breast cancer. Despite years of observation it is still regarded as controversial – not in regard to the very idea; the controversy pertains rather to the way it is being performed by radiation oncologists and surgeons. There are no uniform indications as far as the optimal surgery range is concerned (lumpectomy alone, lumpectomy with the macroscopic margin of 1cm, excision of the breast tissue block of a segment or a quadrant). BCT has produced survival equivalent to mastectomy in the treatment of patients with early-stage invasive breast carcinoma in several randomized Phase III clinical trials. Breast irradiation is an essential element of the conservative approach. Local recurrence risk after surgery alone reaches 35%, compared to 10% in patients undergoing adjuvant radiotherapy [1]. First, the whole breast is irradiated using external beam technique, usually with a dose of 50Gy. Subsequently it is necessary to increase the dose delivered to the tumour bed using a so called “boostâ€.
Study of Weekly Paclitaxel with Concurrent Radiotherapy V/S Weekly Cisplatin with Concurrent Radiotherapy in Advanced Cervix Carcinoma
Purpose: To evaluate the Response and Efficacy of weekly paclitaxel with concurrent radiotherapy in comparison to weekly cislatin with concurrent radiotherapy in advanced cervical cancer patients. Methods: Patients coming to the department of radiotherapy S.M.S Hospital were included in the study.50 patients of advanced squamous cell carcinoma of cervix FIGO stage III &IV were selected. In the study and control group , patients were given 5 weeks of external beam radiotherapy followed by brachytherapy. External beam irradiation each of 200cGy/fr, on linear acceleretor by parallel opposed – anterior and posterior fields was given. External beam irradiation was followed by Intracavitary brachytherapy 700cGy/week for 3 weeks each with High Dose Rate Iridium 192 source. Patients received 50 Gy by External beam irradiation (200cGy/fr, total 25 Fr) and 21 Gy by Intracavitary brachytherapy (7Gy/fr, 3fr) .In control group, patients were treated by concurrent weekly cisplatin with external beam radiotherapy.In study group patients were treated by concurrent weekly paclitaxel with external beam radiotherapy.
