Research
A Study of Clinical and Laboratory Profile of Dengue Fever in Tertiary Care Hospital in Central Karnataka, India
Objective: To evaluate the clinical and laboratory profile of dengue in the central Karnataka region of South India. Materials and Methods: It is a prospective study was carried out between July-October, 2013 in BMCH & RC in central Karnataka. The study included seropositive dengue fever inpatients admitted in the medical wards in the age group of 18- 75 yrs. The test kit used for the sero diagnosis of dengue was “Dengue day 1 test kit (J. Mitra & co. Pvt. Ltd.)†which shows NS1, IgM and IgG reactivity towards dengue fever. Result: Out of 146 seropositive cases, 92 were males and 54 were females. Most of the cases reported in young age groups (i.e. 20-30 years) compared to other age groups. NS1 antigen, IgM and IgG antibody was found reactive in 112 (76.71%), 2 (1.36%) and 6 (4.10%) patients respectively. The commonest presenting clinical symptoms in patients are fever (in all patients, 100%), severe headache (n=110, 75.34%), Nausea/Vomiting (n=84, 57.53%) and Fatigue (n=68, 46.57%). The bleeding manifestations were found in 14 patients (9.58%) which includes Gum bleeding, Hematuria, Hematemesis and Malena. Bleeding manifestations was associated with severe thrombocytopenia, were in 33.33% of patients. Discussion: Early recognition and prompt management is essential to reduce the morbidity and mortality associated with disease.
Study of Serum Magnesium in Type 2 Diabetes Mellitus and its Correlation With the Modality of Treatment- A South Indian Study
Introduction: Hypomagnesaemia has been reported to occur with increased frequency in patients with type 2 diabetes mellitus; it is frequently overlooked and undertreated. Materials and Methods: A total of 50 patients with type 2 Diabetes Mellitus were recruited from the institute’s medicine department. Fifty age and sex matched apparently healthy individuals with normal plasma glucose and with no symptoms suggestive of Diabetes mellitus were taken as controls. Both cases and controls were subjected to estimation of biochemical parameters. Objectives: The present study was conducted with an objective to evaluate the serum magnesium and fasting blood glucose in type 2 Diabetes mellitus cases and compare them with controls. The present study also attempts to evaluate the possible relationship between the modality of treatment and serum magnesium levels. Results: There is significant difference between levels of serum magnesium levels among diabetics and controls. The mean serum magnesium levels in cases and controls are 1.67 mg/dl and 2.03 mg/dl respectively (p<0.001). The mean serum magnesium levels in the OHA group, insulin group and the insulin+ OHA group were 2.02 mg/dl,1.59mg/dl and 1.25 mg/dl respectively. Conclusion: The serum magnesium levels were significantly lower in the insulin treated group compared to the OHA treated group. The serum magnesium levels were also significantly lower in insulin treated group compared to the OHA group.
