Bio
Ngnaniyyi Abdoul is a researcher based at the University of Dschang in Cameroon, where he investigates the cytogenotoxic and antimeiotic properties of plant extracts. His work focuses on understanding how natural compounds from species such as muskmelon (Cucumis melo L.) and bitter kola (Garcinia kola) affect cell division, growth, and chromosomal stability in model organisms like Allium cepa and the pest grasshopper Zonocerus variegatus. He has published two papers exploring the mitotic inhibition and chromosomal abnormalities induced by muskmelon root extract, as well as the antimeiotic effects of aqueous extracts from different plant parts. Additionally, he serves as a reviewer for the Global Journal of Science Frontier Research (GJSFR) and has expertise spanning cytogenetics, plant science, entomology, and environmental health.
Experience
Research
Antimeiotic Properties of the Aqueous Extracts of Leaves, Fruits and Roots of the Muskmelon Cucumis melo L. (Cucurbitaceae) in the Pest Grasshopper Zonocerus variegatus L. (Pyrgomorphidae)
The Muskmelon, Cucumis melo L., is a Cucurbitaceae widely cultivated in Cameroon for its nutritional and ethnomedicinal benefits. Species of Cucurbitaceae are known to contain several bioactive molecules that include the terpenoid cucurbitacins, which has been shown to cause significant molting defects and mortality in a variety of Coleoptera insect species such as Leperesinus fraxini PANZ(Coleoptera, Scolytidae) Stereonychus fraxini DE GEER (Coleoptera, Curculionidae). This study was designed to determine if an aqueous extract of Muskmelon, C. melo var. Cantaloupensis Americana, could profoundly affect the meiotic process in the Orthoptera grasshopper Zonocerus variegatus, a veritable food crop pest in Africa south of the Sahara. Different concentrations (0 μg/ml, 5 μg/ml, 10 μg/ml, 20 μg/ml, 30 μg/ml, and 40 μg/ml) of aqueous extract of the leaves, fruits, and roots of C. melo were, respectively injected using the intraperitoneal method (into the hemocoel) of new reproductive and adult male individuals of Z. variegatus. Cytogenetic analysis revealed that Muskmelon extracts significantly reduced meiotic indexinduced meiotic chromosome abnormalities and significantly reduced chiasma frequency. Chromosome abnormalities recorded included sticky chromosomes, Anaphase 1bridges, and laggards. The 40 μg/ml extract of roots was the most cytotoxic and induced the production of ghost cells. These results indicated that the aqueous extracts of C. melo are potential meiotic regulators that can affect fertility in the pest species Z. variegatus.
Musk Melon Root Extract (Cucumis Melo L.) Inhibits Mitosis and Growth of Meristematic Cells in the Allium Cepa Essay through Chromosomal Abnormalities
Background: The Musk melon, Cucumis melo, is an essential herbaceous plant species in Cameroon for its nutritional and ethnomedicinal values. Thus, roots of this plant are not edible but are used in treating many local ailments. To date, there has been no report on the cytotoxicity and genotoxicity of the roots of Musk melon. Therefore, this study was to investigate the potential cytotoxic and genotoxic effects of aqueous extracts of the roots of C. melo using the Allium cepa assay. Allium bulbs were treated with six concentrations (0 µg/ml, five µg/ml, ten µg/ml, 20 µg/ml, 30 µg/ml, and 40 µg/ml) of aqueous extract of the roots of C. melo for 96 hours and distilled water was used as the control. Results: The results showed significant dose-dependent (p<0.05) inhibition of sprouting and growth of roots as well as mitodepressive effects on cell division in A. cepa root tip cells treated with aqueous extract of the roots of C. melo. The results also revealed a significant increase in the dose-dependent frequency of chromosome aberrations (Anaphase bridges, laggards, disorientation, sticky metaphase, and binucleation) in the A. cepa root tip cells. Conclusions: This study revealed that C. melo roots have a clastogenic effect on the root tip cells of A. cepa. The following research will test this extract on a few cancers induced in Wistar rats.
