Research
Antioxidant Activity of Aqueous Extract of Blighia Sapida Stem Bark in Alloxan-Induced Diabetic Rats
Blighiasapida is a plant belonging to the family of sapindaceae. In this study we aimed to evaluate thein vivo antioxidant activitiesof aqueous extract of Blighiasapida stem bark in alloxan-induced diabetic rats. Administration of the extract at 100mg/kg body weight significantly (P<0.05) increased the activities of antioxidant enzymes catalase, glutathione peroxidase and superoxide dismutase in the kidney and pancreas tissues of diabetic rats. Also the concentration of reduced glutathione increased in the kidney and pancreas tissues of the diabetic rats while the levels of malondialdehyde and protein carbonyl generally decreased in the kidney and pancreas tissues of alloxan-induced diabetic rats during the course of the experiment. These are indications of antioxidant properties of the stem bark of Blighiasapida with 100mg/kg body weight of the aqueous extract showing good antioxidant activities by comparing favourably well with metformin, a standard antidiabetic drug.
Phytochemical Screening and in Vitro Antioxidant Activity of Aqueous Extract of Blighia Sapida Stem Bark
Blighia sapida is a plant belonging to the family of sapindaceae. In this study we aimed to carry the phytochemical screening of aqueous extract of Blighia sapida stem bark and evaluate its in vitro antioxidant activity. It was found that the aqueous extract of Blighia sapida stem bark showed the presence of tannin, saponin, flavonoid, alkaloid, phenols and ascorbic acid. It also contains trace elements zinc and selenium. Furthermore it showed some scavenging activity but not as such could be compared with the various standards used except for nitric oxide scavenging activity. These are indications that the aqueous extract ofBlighia sapida contains some physiologically significant secondary metabolites and also possesses appreciable in vitro antioxidant activity.
Anti-Hyperglycemic and in Vivo Antioxidant Activities of Aqueous Extract of Blighia sapida Stem Bark in Alloxan-Induced Diabetic Rats
Blighiasapida is a plant belonging to the family of Sapindaceae. This study is aimed at evaluating the hypoglycemic and possible in vivo antioxidant activities of the aqueous extract of the stem bark of the plant for 21 days in alloxan-induced diabetic rats. Administration of the extract at 100mg/kg body weight significantly (P<0.05) decreased blood glucose levels, increased body weight as well as increased the activities of antioxidant enzymes catalase, glutathione peroxidase and superoxide dismutase in the plasma and liver tissues of diabetic rats. Also, the concentration of reduced glutathione increased in the plasma and liver tissues of the diabetic rats while the levels of malondialdehyde and protein carbonyl significantly decreased in the plasma and liver tissues of alloxan-induced diabetic rats during the course of the experiment. These are indications of antihyperglycemic and antioxidant properties of the stem bark of Blighiasapida with 100mg/kg body weight of the extract showing good hypoglycemic and antioxidant activities by comparing favourably well with metformin, a standard hypoglycemic drug.
