Vitiligo is an acquired depigmentation of the skin. It affects 1% of the world population. It is a pigmentary disorder characterized by circumscribed loss of melanin pigment secondary to melanocyte attrition. It is an acquired, sometimes familial condition, an autoimmune disease in the majority. Vitiligo is associated with other autoimmune diseases such as thyroid disease, diabetes mellitus, Addison’s disease, and pernicious anemia. In Ayurveda, Shvitra is correlated by vitiligo.Shvitra is caused by the vitiation of all three Doshas but sometimes it manifest by either single or three or two Doshas. In modern medicine, steroids and corticosteroids are used in the treatment of vitiligo, which has so many side effects. In Shvitra, Samshodhana (purificatory therapies) for the entire body should be administered at the beginning of treatment of Shvitra after that applied Samshamana therapy.