A New View Duchenne Muscular Dystrophy

Leonora Grinio Ph

A New View Duchenne Muscular Dystrophy

Leonora Grinio Ph *

Contact

Article Fingerprint

ReserarchID

Y00B5

A New View Duchenne Muscular Dystrophy Banner

Key Research Insights

Synthesized scholarly intelligence & interactive research assistant

Abstract

Duchenne Muscular Dystrophy is the result of mutation gene-dystrophine, productprotein-dystrophin presents in organism as the complexes proteins placing everywhere, their role unclear. Suppose all dystrophine complexes work as one functional System D, thanks signal ability complexes. Suppose the System D the ancient and appeared when the gene dystrophin-utrophin divided into two genes dystrophin and utrophin at early vertebrates. Perfect this System made the gene the longest in human genome. The surprising activity creat inkinase-21-23 000 ME, found by author, make to think of the damage much membranesdamage System. Destroy System D is beginning of the disease, finishing apoptosis-general destructive factor. Two factors determinate the disease-damage the system D and apoptosis.

References

48 Cites in Article

Reference Format

L Kunkel (1986). Analysis of deletions in DNA from patients with Becker and Duchenn Muscular Dystrophy.
Eric Hoffman,Robert Brown,Louis Kunkel (1987). Dystrophin: The protein product of the duchenne muscular dystrophy locus.
Кoenigm Kunkel,L (1990). / detailed analysis of the rapid domain of dystrophin reveals four potential hinge segmsnts that may confer flexibility.
Rumeir Winder,S Hubert,J Dystrophin (2012). Unknown Title.
Derek Blake,Andrew Weir,Sarah Newey,Kay Davies (2002). Function and Genetics of Dystrophin and Dystrophin-Related Proteins in Muscle.
Lidovh,T Byers,L Kunkel (1990). The distribution of dystrophin in the murine central nervous system cortical neurons.
G Banks,P Gregorevic,J Allen,E Finn,J Chamberlain (2007). Functional capacity of dystrophins carrying deletions in the N-terminal actin-binding domain.
B Niels,S Takedo,T Yokota (2015). Nonmechanicalrols of Dystrophin and associated proteins in exercise neuromuscular junctions and brain BrainSci.
V Sojos,M Curto,C Reali,F Gremo (2002). Developmentally regulated expression and localization of dystrophin and utropin in the human fetal brain.
Xaver Koenig,Janine Ebner,Karlheinz Hilber (2018). Voltage-Dependent Sarcolemmal Ion Channel Abnormalities in the Dystrophin-Deficient Heart.
Maaike Van Putten,Elizabeth Van Der Pijl,Margriet Hulsker,Ingrid Verhaart,Vishna Nadarajah,Louise Van Der Weerd,Annemieke Aartsma-Rus (2014). Low dystrophin levels in heart can delay heart failure in mdx mice.
R Hendriksen,S Schipper,G Hoogland (2016). Dystrophin distribution and expression in human.
Waite Blaked,S Brown (2012). The dystrophinglucoprotein complex in brain development and disease.
Kevin Culligan,Louise Glover,Paul Dowling,Kay Ohlendieck (2991). Brain dystrophin-glycoprotein complex: Persistent expression of β-dystroglycan, impaired oligomerization of Dp71 and up-regulation of utrophins in animal models of muscular dystrophy.
Basil Darras,Caroline Menache-Starobinski,Veronica Hinton,Louis Kunkel (2011). Dystrophinopathies.
I Tracey,J Dunn,G Radda (1996). Brain metabolism is abnormal in the <i>mdx</i> model of Duchenne muscular dystrophy.
R Wicksell,M Kihlgren (2004). Specific cognitive deficits are common in children with Duchenne Muscular Dystrophy.
M Sekiguochi,K Zushide,M Yoshida (2009). A deficit of brain dystrophin impairs specific amygdala GABAergic transmission and enhances defensive behavior in mice.
G Banks,P Gregorevic,J Allen,E Finn,J Chamberlain (2007). Functional capacity of dystrophins carrying deletions in the N-terminal actin-binding domain.
L Grinio (1998). A new hypothesis of duchenne muscular dystrophy.
L Grinio (2019). The pathogenesis of Duchenne muscular dystrophy.
Yuka Morikawa,Todd Heallen,John Leach,Yang Xiao,James Martin (2017). Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation.
Valeria Sogos,Monica Curto,Camilla Reali,Fulvia Gremo (2002). Developmentally regulated expression and localization of dystrophin and utrophin in the human fetal brain.
Nadia Milad,Zoe White,Arash Tehrani,Stephanie Sellers,Fabio Rossi,Pascal Bernatchez (2017). Increased plasma lipid levels exacerbate muscle pathology in the mdx mouse model of Duchenne muscular dystrophy.
Goodnough Gao,Y Qutaish,Q (2014). Lack dystrophin results in abnormal cerebral diffusion and perfusion in vivo.
A Gambardelle (2019). Dystrophin distribution and expression in human and experimental temporal lobe.
T Haenggi,J-M Fritschy (2006). Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue.
Kevin Culligan,Louise Glover,Paul Dowling,Kay Ohlendieck (2001). Brain dystrophin-glycoprotein complex: Persistent expression of β-dystroglycan, impaired oligomerization of Dp71 and up-regulation of utrophins in animal models of muscular dystrophy.
Jeffery Goldstein,Elizabeth Mcnally (2010). Mechanisms of muscle weakness in muscular dystrophy.
Yuka Morikawa,Todd Heallen,John Leach,Yang Xiao,James Martin (2017). Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation.
Jennifer Anderson,Stewart Head,John Morley (2009). Long-term depression is reduced in cerebellar Purkinje cells of dystrophin-deficient mdx mice.
A Gambardelle (2019). Dystrophin distribution and expression in human and experimental temporal lobe.
Y Ujhara (2020). Estimation of fukutin reveals cellular and molecular pathomechanims in muscular dystrophy.
S Vican,G Piccini,E Mercuri,P Alfieri (2018). Implacit learning deficit in children with Duchenne Muscular Dystrophy: evidence for a cerebellar cognitive impairtment.
A Pins,P Spitali (2015). Circulating biomarkers for Duchenne Muscular Dystrophy.
David Allen,Nicholas Whitehead,Stanley Froehner (2016). Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca<sup>2+</sup>, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy.
Simon Guiraud,Kay Davies (2019). Regenerative biomarkers for Duchenne muscular dystrophy.
Miranda Grounds,Jessica Terrill,Basma Al-Mshhdani,Marisa Duong,Hannah Radley-Crabb,Peter Arthur (2020). Biomarkers for Duchenne muscular dystrophy: myonecrosis, inflammation and oxidative stress.
S Savitz,B Daniel,M Rosenbaum (1998). Apoptosis in neurological siseases.
Mark Arends,Andrew Wyllie (1991). Apoptosis: Mechanisms and Roles in Pathology.
Ho Tang,Ho Tang,Keng Mak,Shaomin Hu,Shan Wang,Kit Wong,Chung Wong,Hoi Wu,Hiu Law,Kan Liu,C Talbot,Wan Lau,Denise Montell,Ming Fung (2012). Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response.
G Borras (2006). Programmed cell death in plants and animals.
V Soyos,M Curto,C Reali,F Grenio (2002). Developmentally regulated expression and localization of dystrophin and utropin in the human fetal brain.
N Milad,Z White,A Tehrani,F Rossi (2017). Increased plasma lipid levels in the mdx model.
Goodnough Gao,Y Qutaish,Q (2014). Lack dystrophin results in abnormal cerebral diffusion and perfusion in vivo.
A Gambardelle (2019). Dystrophin distribution and expression in human and experimental temporal lobe.
T Haenggi,J-M Fritschy (2006). Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue.
Kevin Culligan,Louise Glover,Paul Dowling,Kay Ohlendieck (2001). Brain dystrophin-glycoprotein complex: Persistent expression of β-dystroglycan, impaired oligomerization of Dp71 and up-regulation of utrophins in animal models of muscular dystrophy.

Download References

Funding

No external funding was declared for this work.

Conflict of Interest

The authors declare no conflict of interest.

Ethical Approval

No ethics committee approval was required for this article type.

Data Availability

Not applicable for this article.

How to Cite This Article

Leonora Grinio Ph. 2021. "A New View Duchenne Muscular Dystrophy". Global Journal of Science Frontier Research - C: Biological Science GJSFR-C Volume 21 (GJSFR Volume 21 Issue C4).

More Citation Formats

Select Citation Style:

Download Citation

GJSFR Volume 21 Issue C4

Explore Journals Explore Volume Read This Issue

Journal Specifications

Crossref Journal DOI 10.17406/GJSFR

Print ISSN 0975-5896

e-ISSN 2249-4626

Keywords

Not Found

Classification

GJSFR-C Classification FOR Code: 279999

Submission ReceivedJuly 6, 2021
Peer Review Double Blind
Handling Editor
Accepted August 5, 2021
Published August 20, 2021

Version of record

v1.2

Issue date

October 4, 2021

Language

English

Experiance in AR

Explore published articles in an immersive Augmented Reality environment. Our platform converts research papers into interactive 3D books, allowing readers to view and interact with content using AR and VR compatible devices.

View in VR

Read in 3D

Your published article is automatically converted into a realistic 3D book. Flip through pages and read research papers in a more engaging and interactive format.

View in 3D

Article Matrices

Total Views: 662

Total Downloads: 50

All Trends